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| 人参皂苷对皮肤细胞紫外线的辐射损伤的保护作用 | |
| 引用本文： | 叶才果,周湘君,潘海燕,林坚涛,徐秀梅,何志巍.人参皂苷对皮肤细胞紫外线的辐射损伤的保护作用[J].中国热带医学,2009,9(4):636-637. |
| 作者姓名： | 叶才果 周湘君 潘海燕 林坚涛 徐秀梅 何志巍 |
| 作者单位： | 1. 广东医学院中美肿瘤研究所,广东,东莞,523808 2. 广东医学院中药与新药研究所,广东,东莞,523808 3. 广东医学院统计学教研室,广东,东莞,523808 |
| 摘 要： | 目的检测人参皂苷对小鼠皮肤细胞和JB6 C141细胞株的抗紫外线B的损伤作用。方法通过对细胞照射后存活率的检测、单细胞电泳和软克隆集落形成实验，评估人参皂苷对细胞的照射后DNA修复抗损伤能力。以及人参皂苷对EGF诱导的皮肤细胞恶性转化能力的抑制作用。结果人参皂苷能有效地对紫外线B造成的细胞致死性损起抑制作用（P〈0．05），并且对EGF诱导的皮肤细胞转化作用也有明显的抑制作用（P〈0．05）。结论人参皂苷对皮肤细胞抗紫外线辐射损伤的保护作用明显，能显著提高细胞存活率。 |
| 关 键 词： | 人参皂苷 皮肤细胞 JB6细胞 紫外线B |
The protective effects of ginsenoside against damage of skin cells by ultrabiolet B |
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| YE Cai-guo,ZHOU Xiang-jun,PAN Hai-yan,et al..The protective effects of ginsenoside against damage of skin cells by ultrabiolet B[J].China Tropical Medicine,2009,9(4):636-637. | |
| Authors: | YE Cai-guo ZHOU Xiang-jun PAN Hai-yan |
| Institution: | 1.Zhongmei Tumor Institute of Guangdong Medical College;Dongguan 523808;Guangdong;P.R.China |
| Abstract: | Objective To investitate the protective effect of ginsenoside on the survival rate and the level of mouse primary culture cells and JB6 C141 cells by ultraviolet B(UVB) radiation.Methods After UVB radiation,the DNA repairing ability and the EGF-promoted colony formation capacity were analysed.Results ginsenoside could effectively protect the cells from damage by UVB radiation(P <0.05) and inhibit EGF-promoted colony formation rate(P <0.05).Conclusion Ginsenoside is capable of protecting cells from damage by... |
| Keywords: | Ginsenoside Skin cells JB6 cell Ultraviolet B |
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