穿心莲提取物的药效学研究

目的:研究穿心莲提取物的药效学作用。方法:通过解热、抗炎、镇咳、祛痰、抗病毒和免疫调节等相关试验,研究了穿心莲提取物的药效作用。结果:穿心莲提取物对酵母菌引起的大鼠发热有明显的对抗作用,作用长达6h。对冰醋酸诱导的腹腔毛细血管通透性增高有明显的抑制作用;可明显减轻角叉菜胶诱导的大鼠足肿胀;显著抑制棉球肉芽肿增生;明显抑制浓氨水诱导的小鼠咳嗽和枸橼酸钠诱导的豚鼠咳嗽;可使流感杆菌感染小鼠的肺脏炎症明显减轻;对环磷酰胺造成的小鼠溶血素抗体分泌低下具有明显的促进作用;增强巨噬细胞的吞噬功能。结论:穿心莲提取物有明显的解热、抗炎、镇咳、抗病毒和免疫调节作用。

A Pharmacodynamic Study on Extract from Andrographis paniculata Nees

Objective:To study the pharmacological effects of extract from Andrographis paniculata Nees.Methods:By using antipyretic,anti-inflammatory,expectorant,antiviral,and immunomodulatory experiments,the pharmacological effects of extract from Andrographis paniculata Nees were investigated.Results:The extract from Andrographis paniculata Nees significantly inhibited yeast-induced fever in rats,and it lasted to 6 h.The extract significantly inhibited acetic acid-induced increase in capillary permeanbilitly in abdominal cavity of mice, inhibited carrageenin-induced foot swelling and cotton ball granulomatous hyperplasia in rats,suppressed the cough induced by ammonia solution in mice and the cough induced by sodium citrate in guinea pig,decreased the times of cough and increased cough latent period respectively,reduced lung inflammation induced by influenza virus in mice,increased the hemolysin antibody secretion of splenic lymphocyte in mice against the antibody secretion decreasing induced by cyclophosphamide in mice,enhanced phagocyte function of macrophage.Conclusion:The extract from Andrographis paniculata Nees demonstrates the effects of antipyretic,anti-inflammatory,expectorant,antiviral,and immunomodulatory.