Measurement of placental alkaline phosphatase in maternal plasma as an indicator of subsequent low birthweight outcome

Summary. Placental alkaline phosphatase (P-ALP) was measured by a specific monoclonal antibody-based immunoassay in plasma samples of 117 women who subsequently were delivered of an infant of birthweight less than 2·5 kg. P-ALP values > twice the normal median were found in 32% of maternal plasma samples from low birthweight cases in one scries and in 35% in another series, while in normal outcome controls the corresponding value was 8%. The differences were highly significant. The proportion of low birthweight cases with elevated maternal P-ALP values appears to be very similar between 15 and 34 weeks gestation. At 16–18 weeks gestation there is a significant positive correlation (r = 0·40) between P-ALP and maternal plasma alpha-fetoprotein (AFP) values in low birthweight cases. The use of P-ALP assay in combination with AFP assay appears to improve the detection of pregnancies with subsequent low birthweight outcome.