| 多奈哌齐联合阿托伐他汀治疗中重度阿尔茨海默病的疗效和安全性 |
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| 引用本文： | 赵晓玲,刘艳.多奈哌齐联合阿托伐他汀治疗中重度阿尔茨海默病的疗效和安全性[J].实用医院临床杂志,2011,8(3):52-54. |
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| 作者姓名： | 赵晓玲 刘艳 |
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| 作者单位： | 成都市第三人民医院神经内科,四川,成都,610031 |
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| 摘 要： | 目的探讨多奈哌齐联合阿托伐他汀治疗中、重度阿尔茨海默病(Alzheimer disease,AD)患者的疗效及安全性。方法 44例中、重度AD患者采用随机数字表法分为联合用药组和多奈哌齐组。治疗前和治疗24周后分别进行血脂水平、简易精神状态量表(Mini-Mental State Examination,MMSE)、日常生活能力量表(activity of daily living,ADL)及全面衰退量表(global deterioration scale,GDS)的检测和评分,并进行比较。结果联合用药组治疗前后的血脂水平差异有统计学意义(P<0.05),而多奈哌齐组则无统计学意义(P>0.05);每组治疗前后的MMSE、ADL及GDS评分比较,差异均有统计学意义(P<0.05);两组治疗后的各项评分比较,差异同样有统计学意义(P<0.05)。结论多奈哌齐联合阿托伐他汀能有效改善中、重度AD患者的认知功能和日常生活能力,效果优于单独使用多奈哌齐,且安全性高。
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| 关 键 词： | 多奈哌齐 阿托伐他汀 阿尔茨海默病 痴呆 |
Effect of Donepezil and Atrovastatin on moderate or severe Alzheimer disease and its safety |
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| ZHAO Xiao-ling,LIU Yan.Effect of Donepezil and Atrovastatin on moderate or severe Alzheimer disease and its safety[J].Practical Journal of Clinical Medicine,2011,8(3):52-54. |
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| Authors: | ZHAO Xiao-ling LIU Yan |
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| Institution: | ZHAO Xiao-ling,LIU Yan (Department of Neurology,Third People's Hospital of Chengdu,Chengdu 610031,China) |
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| Abstract: | Objective To explore the efficacy and safety of Donepezil combined with Atrovastatin on patients with moderate or severe Alzheimer disease.Methords Forty-four patients with moderate or severe Alzheimer disease were randomly divided into combination(Donepezil combined with Atrovstatin)group and Donepezil group.Results of blood lipid level,Mini-Mental State Examination(MMSE),activity of daily living(ADL)and global deterioration scale(GDS)were compared respectively between the two groups before and after treat... |
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| Keywords: | Donepezil Atrovstatin Alzheimer disease Dementia |
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