透析液流量对血液透析充分性的影响

目的探讨提高透析液流量对血液透析患者透析充分性的影响。方法选择我院长期规律维持性血液透析患者30例,血流量为350-400 ml/min,透析液流量从常规500 ml/min增加至800 ml/min进行13周,其他透析参数（透析时间、血流量、透析器、超滤量）及药物治疗不变。增加透析液流量的前两周及增加后的第12和13周测定透析前后（每周最后一次透析时采集标本）尿素氮、肌酐,并记录每次透析的时间、超滤量、透后体重,再计算出尿素清除指数（Kt/V）和尿素下降率（URR）,取两次测定值的平均值,观察透析液流量对Kt/V和URR的影响。结果透析液流量为800 ml/min时Kt/V值和URR较透析液流量为500 ml/min时有所增加,差异有统计学意义（P〈0.05）。结论透析液流量从500 ml/min增加至800ml/min,可增加Kt/V值和URR,提高血液透析充分性。对于不便增加透析时间和提高血流量的维持性血液透析患者,可增加透析液流量为800 ml/min来提高血液透析充分性。

Influence of dialysate flow on the effect of hemodialysis

Objective To discuss the influence of dialysate flow on the effect of hemodialysis.Methods We chose 30 patients with long-term regular hemodialysis in our department(blood flow:350~400 ml/min),and changed the dialysate flow for them from 500 ml/min to 800 ml/min for 13 weeks.Other dialysis parameters(dialysis time,blood flow,dialyzer,ultrafiltration)and medication were unchanged.We tested urea nitrogen,creatinine(collected at the last dialysis of every week)before and after dialysis on the first two weeks b...