An illustration of dangers of ignoring survival differences in carcinogenic data |
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| Authors: | A J Bailer C J Portier |
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| Affiliation: | Division of Biometry and Risk Assessment, National Institute of Environmental Health Sciences, NC 27709. |
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| Abstract: | This paper illustrates the effects of survival differences on the routine analysis of 2-year animal carcinogenesis experiments using quantal response. Not adjusting for decreased survival in the higher dosed groups results in a decrease in the actual significance level for the quantal response trend test, and a corresponding decrease in sensitivity for detecting a true treatment effect. Similar results hold for estimation of carcinogenic risk. Tables of the range of survival differences found in recent National Toxicology Program carcinogenesis studies are presented. |
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