The changing pattern of diagnosis of infantile cholestasis |
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Authors: | Stormon M O Dorney S F Kamath K R O'Loughlin E V Gaskin K J |
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Institution: | Department of Gastroenterology, Royal Alexandra Hospital for Children, Parramatta, New South Wales, Australia. |
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Abstract: | OBJECTIVE: Cholestatic liver disease in infancy is caused by a wide range of conditions. This study reviews the pattern of diagnosis of infants with cholestasis presenting to a tertiary referral paediatric hospital in Sydney, Australia, during a 12-year period (1985-96). METHODOLOGY: Infants aged less than 6 months with cholestasis were identified retrospectively from hospital records and data retrieved from the medical records. RESULTS: There were 205 infants identified as having cholestatic liver disease. The aetiology of the cholestasis was idiopathic in 25%, metabolic/genetic in 23%, and due to obstruction in 20%, parenteral nutrition in 20%, infection in 9% and bile duct hypoplasia in 3%. CONCLUSIONS: This study highlights the changing patterns of diagnosis of cholestatic liver disease in infants at a tertiary paediatric facility, demonstrating that up to 50% of cases are now due to genetic/metabolic diseases or parenteral nutrition, and a high proportion are due to idiopathic disease. |
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Keywords: | biliary obstruction bile duct hypoplasia cholestasis genetic metabolic disease liver disease neonatal |
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