| 光动力学疗法对大鼠W256移植瘤的生长和GSH—PX活性的影响 |
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| 引用本文： | 崔瑞耀,沈芳臻.光动力学疗法对大鼠W256移植瘤的生长和GSH—PX活性的影响[J].中国病理生理杂志,1997,13(6):635-637. |
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| 作者姓名： | 崔瑞耀 沈芳臻 |
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| 作者单位： | 青岛医学院病理生理学教研室!青岛，266021，青岛医学院附院肿瘤科!青岛，266021，青岛医学院病理生理学教研室!青岛，266021，青岛医学院病理生理学教研室!青岛，266021，青岛医学院附院肿瘤科!青岛，266021 |
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| 摘 要： | 用光动力学疗法（ｐｈｏｔｏｄｙｎａｍｉｃｔｈｅｒａｐｙ，ＰＤＴ）对Ｗ２５６移植瘤进行治疗，并观察Ｗ２５６移植瘤的生长速度和检测大鼠血和肝组织中谷胱甘肽过氧化物酶（ＧＳＨ－ＰＸ）的活性，结果如下：（１）接受ＰＤＴ治疗组大鼠Ｗ２５６移植瘤生长缓慢Ｐ〈０．０５），（２）接受ＰＤＴ治疗组大鼠血和肝组织中的ＧＳＨ－ＰＸ活性显著低于肿瘤对照组大鼠（Ｐ〈０．０１），而肿瘤对照组大鼠血和肝组织中ＧＳＨ－ＰＸ活性又
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| 关 键 词： | 大鼠 肿瘤 光动力学疗法 GSH－PX |
Effects of photodynamic therapy on the growth of W256 transplant tumor and glutathione peroxidase activity in rats |
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| Cui Rut -Yao, Shen Fang-Zhen, Xu Luo, Xia Bing, Tao Shang-Min,Wang Yu- Zhen, Chen Wei - Gang.Effects of photodynamic therapy on the growth of W256 transplant tumor and glutathione peroxidase activity in rats[J].Chinese Journal of Pathophysiology,1997,13(6):635-637. |
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| Authors: | Cui Rut -Yao Shen Fang-Zhen Xu Luo Xia Bing Tao Shang-Min Wang Yu- Zhen Chen Wei - Gang |
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| Abstract: | The effects of photodynamic therapy (PDT) on the rats with W256 transplant-tumor were studied. It was found that the tumor grew slower (P<0.05) and the activity of glutathione peroxidase (GSH-PX) in blood and liver tissue was lower (P<0.01) in PDT group than that of the tumor control group, which was in turn than that of the normal control group (P<0.05,p<0.01). These results suggested that PDTmay have an suppressive effect on the growth of transplant-tumor. |
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| Keywords: | Photochemotherapy Glutathione peroxidase Rats Neoplasms |
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