| 哮喘豚鼠结状神经节,脊神经节和中枢内神经激肽A含量变化 |
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| 引用本文： | 方秀斌,王振宇,晓杰,王铁民,高杰,姜乃春.哮喘豚鼠结状神经节,脊神经节和中枢内神经激肽A含量变化[J].中国病理生理杂志,1997,13(6):607-610. |
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| 作者姓名： | 方秀斌 王振宇 晓杰 王铁民 高杰 姜乃春 |
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| 作者单位： | 中国医科大学脑研究所!沈阳，11001，中国医科大学脑研究所!沈阳，11001，中国医科大学脑研究所!沈阳，11001，中国医科大学脑研究所!沈阳，11001，中国医科大学脑研究所!沈阳，11001，沈阳市红十字会医院 |
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| 基金项目： | 国家自然科学基金!39270338 |
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| 摘 要： | 应用放射免疫分析方法，检测16只哮喘豚鼠一级传入系统和中枢内神经激肽A（NKA）的水平。与正常对照组（结状神经节62．82±11.09pg/gw.w，C7～C8段脊神经节53．78±12．63，T1～T2段脊神经节54．23±19．08，T3~T5段脊神经节50．53±14．23pg／gw．w;C7～T5段脊髓后角45．86±19．56，孤束核55．27±19．68pg/gw．w．和延髓腹侧浅层37.36±18．29pg/gw．w．）相比，哮喘豚鼠一级传入系统和中枢内（结状神经节83．81±15．23pg/gw．w．C7～C8段脊神经节72．11±17．16．T1～T2段脊神经节73．95±23．76，T3～T5段脊神经节70.53±14．23pg／gw．w，C7~T5段脊髓后角60.25±21．38pg／gww．孤束核71．36±18．76pg／gw．w和延髓腹侧线层49．58±20．19pg／gw．w．）NKA水平明显升高（P＜0．05）．这些结果提示，一级传入系统和中枢内的NKA可能参与哮喘的发病机制。
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| 关 键 词： | 神经激肽A 中枢神经系统 哮喘 |
Alteration of neuokinin A level in the primary afferent system and central nervous system of asthmatic guinea pig |
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| Fang Xiu-Bin, Wang Zheng-Yu, Tong Xiao-Jie, Wang Tie-Min,.Alteration of neuokinin A level in the primary afferent system and central nervous system of asthmatic guinea pig[J].Chinese Journal of Pathophysiology,1997,13(6):607-610. |
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| Authors: | Fang Xiu-Bin Wang Zheng-Yu Tong Xiao-Jie Wang Tie-Min |
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| Abstract: | The neurokinin A (NKA) level in the primary afferent system and central nervous system in asthmatic guinea pigs were measured by means of rallioimmunoassay. The results showed that compared with the contral group the NKA level was much higher in asthmatic group. The results indicated that NKA in the primary afferent system and central nervous system might be involved in the pathogenesis of asthma. |
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| Keywords: | Neurokinin A Central nervous system Asthma |
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