Reversed-phase high-performance liquid chromatographic method for the assay of 1,4-dioxane in sulphated polyoxyethylene alcohol surfactants |
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Authors: | S. Scalia |
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Affiliation: | Dipartimento di Scienze Farmaceutiche, Università di Ferrara, Via Scandiana, 21, 44100 Ferrara, Italy |
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Abstract: | A rapid high-performance liquid chromatographic method has been developed for the assay of 1,4-dioxane in ethoxylated fatty alcohol sulphates. After solid-phase extraction using Bakerbond C18 cartridges, samples were directly analysed on a LiChrospher CH-8 reversed-phase column with UV detection at 200 nm and an acetonitrile-water eluent. Recovery of 1,4-dioxane from the surfactant matrix was 95.7% in the 40 to 120 μg g−1 range. The minimum quantifiable amount was 18 μg g−1. The procedure is simple, reproducible, specific and suitable for routine analyses of commercial surfactants. |
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Keywords: | Reversed-phase high-performance liquid chromatography octadecyl-bonded silica cartridges 1,4-dioxane sulphated fatty alcohol ethoxylate surfactants. |
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