WISKOTT-ALDRICH SYNDROME IN IDENTICAL TWINS: ABNORMALITY OF CD4 AND CD8 POSITIVE LYMPHOCYTES |
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| Authors: | K. FORSYTH R. SESHADRI C. MATTHEWS R. HEDDLE |
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| Affiliation: | Lecturer in Pediatrics and immunology Flinoers Medical Centre. SA;Senior Stall Specialist. Department of Flematology Flinders Medical Centre. SA;Research Assistant, Department of Hematology, Flinders Medical Centre. SA;Senior Visiting Specialist, Department of Immunology, Flinders Medical Centre, SA |
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| Abstract: | The rare occurrence of Wiskott-Aldrich syndrome (WAS) in identical twin brothers without a preceding family history of the disease is described. Investigation into the nature of the lymphocyte abnormality in the surviving twin suggests that the frequency of T cell clone forming cells is markedly decreased. Further analysis of the T cell clones showed a deficiency of CD8 positive cytotoxic/suppressor cells. This alteration may be an underlying mechanism in the development of some of the clinical manifestations of WAS |
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| Keywords: | Wiskott-Aldrich syndrome T cell CD4 positive cell CD8 positive cell suppressor T cell cytotoxic T cell T cell clone infection |
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