冠心病患者动静脉血浆B型利钠肽浓度变化及其意义

目的：初步探讨稳定型冠心病（CAD）患者动静脉血浆B型利钠肽（BNP）浓度的变化及其与冠脉病变的关系。方法：所有患者均经心脏超声和冠脉造影检查，应用化学发光法测定43例经冠脉造影（CAG）证实的稳定型CAD、22例急性冠脉综合征（ACS）和22例CAG正常患者动、静脉（冠状动脉窦和贵要静脉）BNP浓度，收集临床资料，进行统计分析和比较。结果：（1）各组动、静脉血浆BNP浓度无显著差异（P〉0．05）；（2）ACS组动静脉血浆BNP浓度均显著高于CAG正常组和稳定型CAD组（P〈0．01）；（3）稳定型CAD组的动脉血浆BNP浓度显著高于CAG正常组（P〈0．05），但静脉血浆浓度比较无显著差异（P〉0．05）；（4）冠脉病变狭窄程度越严重，BNP浓度越高（P〈0．05）。结论：血浆BNP浓度可能是反映稳定型CAD患者冠脉病变严重程度的一个预测因子。

Plasma B-type natriuretic peptide levels of coronary sinus and perpheral vein in stable coronary artery disease

Objective：To assess the plasma BNP levels of coronary sinus versus peripheral vein in stable coronary artery disease（CAD） and investigate the association between the BNP level and stenosis of coronary artery. Methods： All re-cruited patients underwent echocardiographic examination, and selective coronary angiography was performed. Plasma levels of BNP were measured in 43 patients with stable CAD, 22 patients with acute coronary syndrome（ACS）, and 22 cases without coronary artery disease（ control group）. The data of subjects were collected and analysed. Results： The data showed： （1）BNP levels of coronary artery sinus were no significantly different from that of perpheral vein for all subjects （P〉0.05） ;（2）ACSs group had significantly higher BNP values compared with stable CAD and control group （P〈0.01） ; （3）Plasma BNP level of coronary artery sinus in patients with stable CAD was higher than that of control group （P〈0.05） ; （4）The higher plasma BNP level was associated with the more severity of coronary artery stenosis （P〈0.05）. Conclusion： Plasma BNP level is associated with a more severity of coronary artery disease.