| 花椒毒酚抗炎作用的实验研究 |
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| 引用本文： | 连其深,张志祖,胡晓,周俐,叶和扬,何蔚,朱遵平.花椒毒酚抗炎作用的实验研究[J].中草药,1998,29(2):102-104. |
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| 作者姓名： | 连其深 张志祖 胡晓 周俐 叶和扬 何蔚 朱遵平 |
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| 作者单位： | 赣南医学院药理教研室!赣州340000 |
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| 摘 要： | 花椒毒酚（xanthotoxol，XT）是从蛇床子中提取出的一种呋喃香豆素。XT对二甲苯所致小鼠耳壳肿胀、醋酸引起的小鼠腹腔毛细血管通透性增高、大鼠角叉菜胶性足跖肿胀均有明显的抑制作用，对小鼠棉球肉牙肿增生也有明显的抑制作用。结果表明XT对急性和慢性炎症模型均有抗炎作用。此外，XT明显降低大鼠角叉菜胶性足跖炎症组织内PGE含量。
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| 关 键 词： | 花椒毒酚 抗炎作用 致炎剂 |
| 收稿时间： | 1996/8/13 0:00:00 |
Studies on the Anti-inflammatory Effect of Xanthotoxol in Experimental Animals |
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| Lian Qishen,Zhang Zhizu,Hu Xiao.Studies on the Anti-inflammatory Effect of Xanthotoxol in Experimental Animals[J].Chinese Traditional and Herbal Drugs,1998,29(2):102-104. |
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| Authors: | Lian Qishen Zhang Zhizu Hu Xiao |
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| Institution: | Department of Pharmacology, Ganran Medical College, Ganzhou, 341000;Department of Pharmacology, Ganran Medical College, Ganzhou, 341000;Department of Pharmacology, Ganran Medical College, Ganzhou, 341000;Department of Pharmacology, Ganran Medical College, Ganzhou, 341000;Department of Pharmacology, Ganran Medical College, Ganzhou, 341000;Department of Pharmacology, Ganran Medical College, Ganzhou, 341000;Department of Pharmacology, Ganran Medical College, Ganzhou, 341000 |
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| Abstract: | Xanthotoxol (XT) is a furan-coumarin isolated from the fruit of cnidium monnieri(L. ) Cusson. XT suppressed the swelling of mouse ear induced by xylene,the increase of peritoneal capillary permeability induced by HAc in mice and edema of rat hind paw induced by carrageenan. XT inhibited the proliferation of granuloma induced by imlpanting cotton pellets in mice. These results indicated that XT diminished acute and chronic inflammation in animal models. Furthermore,XT decreased the contents of prostaglandin E in inflammatory tissue of rat hind paw induced by carrageenan. |
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| Keywords: | Xanthotoxol anti-inflammatory effect |
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