Dimethylarginines and inflammation markers in patients with chronic kidney disease undergoing dialysis |
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| Authors: | Yildiz Oner-Iyidogan Pernur Oner Hikmet Kocak Figen Gurdol Seldag Bekpinar Yesim Unlucerci Yasar Caliskan Pinar Cetinalp-Demircan Taner Kocak Aydin Turkmen |
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| Affiliation: | (1) Medical Laboratory Programme, Medical Services Training School, Istanbul University, Cerrahpasa, Istanbul, Turkey;(2) Department of Biochemistry, Istanbul Faculty of Medicine, Istanbul University, Capa, 34093 Istanbul, Turkey;(3) Department of Nephrology, Istanbul University, Capa, 34093, Istanbul, Turkey;(4) Department of Urology, Istanbul University, Capa, 34093, Istanbul, Turkey |
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| Abstract: | The aim of this study was to investigate the pro-oxidant and proinflammatory biomarkers and their relationship with dimethylarginines (DMAs) in patients at various stages of chronic kidney disease (CKD). We studied 114 CKD patients, 36 were hemodialyzed, 41 peritoneal dialyzed and 37 nondialyzed (early stage) CKD patients. The control group consisted of 31 healthy subjects. Plasma levels of asymmetric dimethylarginine (ADMA), symmetric dimethylarginine (SDMA), l-arginine, nitric oxide (NO) and proinflammatory cytokines (TNF-alpha and IL-6) were determined, and their relationships with the degree of disease were evaluated. Both DMAs were at high levels in all CKD patients, whereas arginine concentrations were low in patients undergoing dialysis. Elevated TNF-α and IL-6 in CKD patients were indicative of ongoing chronic inflammatory state. A significant positive correlation between SDMA and creatinine suggests that plasma SDMA level may be an index for renal function. |
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| Keywords: | ADMA SDMA Chronic kidney disease Inflammation Dimethylarginines Dialysis |
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