New lignan glycosides with potent antiinflammatory effect, isolated from Justicia ciliata |
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Authors: | Day S H Chiu N Y Tsao L T Wang J P Lin C N |
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Institution: | School of Pharmacy, Kaohsiung Medical University, Kaohsiung, Taiwan 807, Republic of China. |
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Abstract: | Two new lignan glycosides, 4-O-alpha-L-arabinopyranosyl-(1' "-->2' ')-beta-D-xylopyranosyl-(1' " '-->5' ')-beta-D-apiofuranosyl]diphyllin (1), named ciliatoside A (1), and 4-O-?beta-D-apiofuranosyl-(1' " "-->3' ")-alpha-L-arabinopyranosyl-(1' "-->2' ')]beta-D-xylopyranosyl-(1' " '-->5' ')]-beta-D-apiofuranosyl?diphyllin (2), named ciliatoside B (2), were isolated from the whole plant of Justicia ciliata. The structures of 1 and 2 were determined by spectral and chemical methods. Compounds 1 and 2 strongly inhibited the accumulation of NO(2)(-) in lipopolysaccharide-stimulated RAW 264.7 cells in a concentration-dependent manner with IC(50) values of 27.1 +/- 1.6 and 29.4 +/- 1.4 microM, respectively. |
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