帕瑞昔布钠用于无痛人工流产术的临床观察

目的观察帕瑞昔布钠用于无痛人工流产术的疗效和安全性。方法选择80例自愿要求施行人工流产术患者,随机分为两组,帕瑞昔布钠组（Ⅰ组）,对照组（Ⅱ组）,n=40。Ⅰ组丙泊酚2mg.kg-1和帕瑞昔布钠40mg静脉麻醉,Ⅱ组丙泊酚2mg.kg-1静脉麻醉。观察记录术中心率（HR）、脉搏氧饱和度（SpO2）、呼吸频率（RR）、平均动脉压（MAP）、宫颈松弛程度、人流综合征发生率、丙泊酚用药总量,采用疼痛视觉模拟评分（VAS评分）评定术后6h镇痛效果,以及术后术后出血、恶心呕吐、呼吸抑制等不良反应发生情况。结果 VAS评分术后6h内两组有显著性差异（P〈0.05）;两组异丙酚用药总量有显著性差异（P〈0.05）;两组术中宫颈松弛程度有显著性差异（P〈0.05）;两组人流综合征发生率有显著性差异（P〈0.05）;术中各时点血流动力学MAP、HR、RR、SpO2等无显著性差异（P〉0.05）。结论帕瑞昔布钠用于无痛人工流产术,可明显减少患者术中丙泊酚用量,镇痛效果良好,不良反应少,是安全可行的。

The effects of parecoxib on painless artificial abortion surgery

OBJECTIVE To evaluate the efficacy and safety of parecoxib on painless artificial abortion surgery.METHODS 80 patients scheduled for artificial abortion with pregnancy were divided equally and randomly into two groups.the patients in Group Ⅰ received propofol 2mg·kg-1 and parecoxib 40mg intravenous anesthesia and those in Group Ⅱ received propofol 2mL·kg-1 only.Mean arterial pressure(MPA),heart rate(HR),pulse oxygen saturation(SpO2),respiratory rate(RR),degree of cervix relaxationn,artificial abortion syndrome and total of propofol were record.We used visual analogue scale(VAS)to assess analgesia during the period of postoperative 6h,and the incidence of adverse reaction such respiratory depression,bleeding,nausea and vomiting and so on were recorded.RESULTS As compared to VSA between group I and group Ⅱ,the difference was significant in 6h after operation(P<0.05);Between group I and group Ⅱ,the difference was significant in total of propofol,and the incidence rate of artificial abortion syndrome and degree of cervix relaxation in group I significantly lower than that in group Ⅱ,(P>0.05).Compared with group Ⅱ,vital signs had no significant changes occurred in group I(P>0.05).CONCLUSION It was safe and feasible to give parecoxib in patient underwent painless artificial abortion surgery,it could obviously reduce the total of propofol,with good analgesia and less side effect.