| 慢性乙型肝炎重度和慢加急性肝衰竭患者MELD评分与HBV DNA载量的变化 |
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| 引用本文： | 黄旭明,李学俊,赖菁,雷姿颖,柯伟民,高志良.慢性乙型肝炎重度和慢加急性肝衰竭患者MELD评分与HBV DNA载量的变化[J].实用肝脏病杂志,2010,13(2):114-115,118. |
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| 作者姓名： | 黄旭明 李学俊 赖菁 雷姿颖 柯伟民 高志良 |
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| 作者单位： | 1. 510630,广州市中山大学附属第三医院感染病科;云浮市人民医院感染病科
2. 广州市中山大学附属第三医院感染病科,510630 |
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| 基金项目： | 广东省科技攻关项目(编号:2006B36005022);;国家传染病防治科技重大专项(编号:2008ZX10202) |
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| 摘 要： | 目的了解慢性乙型肝炎重度和肝衰竭患者极期与缓解期HBV DNA载量的变化。方法观察并比较51例慢性乙型肝炎重度和56例慢加急性肝衰竭患者病情极期和缓解期的MELD评分和HBV DNA载量变化。结果慢加急性乙型肝炎肝衰竭患者极期和缓解期MELD评分分别为20.5±4.4分和12.2±6.1分,HBV DNA载量为6.2±1.5log10 copies/ml和4.5±1.5log10 copies/ml,而慢性乙型肝炎重度患者极期和缓解期MELD评分则分别为11.9±3.2分和6.4±3.1分,HBV DNA载量为6.5±1.5log10 copies/ml和4.9±1.8log10 copies/ml。慢加急性乙型肝炎肝衰竭和慢性乙型肝炎重度患者极期和缓解期之间MELD评分和HBV DNA载量均存在差别(t=6.692～13.215,P均0.000)。结论不论慢加急性乙型肝炎肝衰竭还是慢性乙型肝炎重度患者,随着肝病的缓解,其MELD评分明显下降,HBV DNA载量出现显著的自发性下降。
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| 关 键 词： | 慢性乙型肝炎 肝衰竭 重度 HBV DNA载量 |
The changes of HBV DNA loads and MELD scores in patients with chronic hepatitis B |
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| HUANG Xuming,LI Xuejun,LAI Jing,et al..The changes of HBV DNA loads and MELD scores in patients with chronic hepatitis B[J].Journal of Clinical Hepatology,2010,13(2):114-115,118. |
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| Authors: | HUANG Xuming LI Xuejun LAI Jing |
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| Institution: | HUANG Xuming,LI Xuejun,LAI Jing,et al.The Department of Infectious Diseases,The Third Affiliated Hospital,Sun Yat-sen University,Guangzhou 510630,China |
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| Abstract: | Objectives In order to know the changes of HBV DNA in patients with chronic hepatitis B.Methods To observe and compare the model for end-stage liver disease（MELD） scores and HBV DNA loads in 51 cases with acute-on-chronic liver failure and 56 with chronic hepatitis B of severe degree.Results MELD scores in peak and convalescent stages in patients with acute-on-chronic liver failure were 20.5±4.4 and 12.2±6.1,and HBV DNA loads were 6.2 ±1.5 log10 copies/ml and 4.5 ±1.5 log10 copies/ml,respectively;MELD scores in peak and convalescent stages in patients with chronic hepatitis B were 11.9 ±3.2 and 6.4 ±3.1,and HBV DNA loads were 6.5±1.5 log10 copies/ml and 4.9±1.8 log10 copies/ml,respectively（t=6.692～13.215,all P0.000）.Conclusion No matter in patients with acute-on-chronic liver failure or chronic hepatitis B,their serum HBV DNA loads has spontaneously decreased in convalescent stages. |
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| Keywords: | Hepatitis B Model for end-stage liver disease HBV DNA |
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