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Pathologie neuroendokriner Neoplasien |
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| Authors: | PD Dr. M. Anlauf P. Gerlach M. Schott A. Raffel M. Krausch W.T. Knoefel M. Pavel G. Kl?ppel |
| Affiliation: | 1. Institut f??r Pathologie, Endokrines Tumorzentrum am Universit?tsklinikum D??sseldorf, Moorenstr. 5, 40225, D??sseldorf, Deutschland 2. Klinik f??r Endokrinologie, Diabetologie und Rheumatologie, Endokrines Tumorzentrum am Universit?tsklinikum D??sseldorf, D??sseldorf, Deutschland 3. Klinik f??r Allgemein-, Visceral- und Kinderchirurgie, Endokrines Tumorzentrum am Universit?tsklinikum D??sseldorf, D??sseldorf, Deutschland 4. Medizinische Klinik mit Schwerpunkt Hepatologie und Gastroenterologie, Charit?? - Universit?tsmedizin Berlin, Campus Virchow-Klinikum, Berlin, Deutschland 5. Institut f??r Pathologie und Konsultationszentrum f??r Pankreas und Neuroendokrine Tumoren, Klinikum Rechts der Isar, TU M??nchen, M??nchen, Deutschland |
| Abstract: | During the last 5 years the European Neuroendocrine Tumor Society (ENETS) has developed basic recommendations for a standardized pathological diagnosis and classification of neuroendocrine neoplasms (NEN) of the gastroenteropancreatic system. These were included in the novel classification of tumors of the digestive system by the World Health Organization (WHO 2010) and the TNM classification of the union for international cancer control (2009). This review presents the pathology diagnosis regarding (1) basic diagnosis, (2) clinically relevant optional diagnosis, (3) proliferation-based grading, (4) nomenclature and (5) TNM classification. It is emphasized that a standardized diagnosis of NEN, together with clinical and radiological findings, is crucial for prognostic stratification and optimal therapy of patients with NEN. Therefore a close interdisciplinary collaboration is essential. |
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