Sonic Hedgehog signaling pathway: from embryology to molecular targeted therapies |
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Authors: | Watson S Serrate C Vignot S |
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Institution: | 1. Department of Biosciences, Rice University, Houston, TX, United States;2. Department of Bioengineering, Rice University, Houston, TX, United States;1. Ludwig-Maximilians-Universitaet Muenchen, Mikrobiologie, Großhaderner Str. 2-4, 82152, Martinsried, Germany;2. Technical University of Munich, Physics of Complex Biosystems, James-Franck-Str. 1, 85748 Garching, Germany;3. University of Göttingen, Institute for Microbiology and Genetics, Dept. of General Microbiology, Grisebachstr. 8, 37077 Göttingen, Germany |
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Abstract: | It has long been known that the hedgehog signaling pathway is crucial for embryonic development, in both Drosophila and vertebrate systems. During the past few years its implication in carcinogenesis has become clear and today it is acknowledged that this pathway plays a role in the malignant transformation of multiple cell types, either owing to the mutation of some of its components or to its erratic activation. New molecular targeted therapies that inhibit the pathway have shown their unquestionable efficiency in several tumours -among which basal cell carcinoma, medulloblastoma, or pancreatic adenocarcinoma. The assessment of these inhibitors in other types of tumours is currently underway with promising results, suggesting that the Sonic hedgehog signalling pathway may become one of the therapeutic targets of the future. |
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Keywords: | sonic hedgehog thérapie moléculaire ciblée embryogenèse oncogenèse sonic hedgehog molecular targeted therapy embryogenesis oncogenesis |
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