| 下调PTEN基因对全脑缺血大鼠学习记忆能力和CREB表达的影响 |
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| 引用本文： | 陈力学,熊新,桂蓓,周冀英. 下调PTEN基因对全脑缺血大鼠学习记忆能力和CREB表达的影响[J]. 重庆医科大学学报, 2011, 36(6): 673-676 |
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| 作者姓名： | 陈力学 熊新 桂蓓 周冀英 |
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| 作者单位： | 重庆医科大学附属第一医院实验研究中心、重庆市神经病学重点实验室,重庆,400016 |
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| 基金项目： | 重庆市卫生局医学科研资助项目(编号:2009-2-357); 重庆市教委科研资助项目(编号:KJ100316) |
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| 摘 要： | 目的:探讨下调第10号染色体同源丢失性磷酸酶张力蛋白基因(Phosphatase and tensin homolog deleted on chromosome ten,PTEN)对全脑缺血再灌注大鼠学习记忆能力及转录因子环磷酸腺苷反应元件结合蛋白(cAMP response element- binding pro...
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| 关 键 词： | 第10号染色体同源丢失性磷酸酶张力蛋白基因 全脑缺血 体感诱发电位 穿梭箱 转录因子环磷酸腺苷反应元件结合蛋白 |
Effects of PTEN down-regulation on learning and memory abilities and CREB expression in rats with global cerebral ischemia |
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| CHEN Li-xue,XIONG Xin,GUI Bei,ZHOU Ji-ying. Effects of PTEN down-regulation on learning and memory abilities and CREB expression in rats with global cerebral ischemia[J]. Journal of Chongqing Medical University, 2011, 36(6): 673-676 |
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| Authors: | CHEN Li-xue XIONG Xin GUI Bei ZHOU Ji-ying |
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| Affiliation: | CHEN Li-xue,XIONG Xin,GUI Bei,ZHOU Ji-ying(Laboratory Research Center,the First Affiliated Hospital,Chongqing Medical University) |
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| Abstract: | Objective:To investigate the effects of PTEN down-regulation on learning and memory abilities after global cerebral ischemia in rats.Methods:The experimental therapy model after global cerebral ischemia and reperfusion was established by four-vessel occlusion(4VO)after 2 days of pshRNApten injected into the hippocampal cell layer of SD rats.The behavioral effects were measured with somatosensory evoked potential(SEP)and computerized shuttle-training case respectively.The expression of CREB was analyzed by R... |
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| Keywords: | Phosphatase and tensin homolog deleted on chromosome ten(PTEN) global cerebral ischemia and reperfusion somatosensory evoked potential(SEP) active avoiding reaction AAR cAMP response element-binding protein(CREB) |
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