| 核蛋白NSA2在脉络膜新生血管动物模型眼组织的表达研究 |
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| 引用本文： | 陈新科,彭惠,雷博,王隽,付鹏. 核蛋白NSA2在脉络膜新生血管动物模型眼组织的表达研究[J]. 重庆医科大学学报, 2011, 36(6): 704-706 |
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| 作者姓名： | 陈新科 彭惠 雷博 王隽 付鹏 |
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| 作者单位： | 重庆医科大学附属第一医院眼科、眼科学重庆市市级重点实验室,重庆,400016 |
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| 基金项目： | 重庆市卫生局医学科学技术研究资助项目(编号:2010-2-073) |
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| 摘 要： | 目的:NSA2是1种新发现的与细胞增殖相关的核蛋白,本实验旨在初步探讨NSA2是否参与了脉络膜新生血管(Chor-oidal neovascularization,CNV)病变过程.方法:采用532 nm波长的眼底激光对16只小鼠光凝处理,诱导CNV动物模型;小鼠眼底激光光凝处理5d后,去除眼前段,定量PCR检测NSA...
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| 关 键 词： | 脉络膜新生血管 动物模型 核蛋白 |
Expression of NSA2 in a mouse model of choroidal neovascularization |
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| CHEN Xin-ke,PENG Hui,LEI Bo,WANG Juan,FU Peng. Expression of NSA2 in a mouse model of choroidal neovascularization[J]. Journal of Chongqing Medical University, 2011, 36(6): 704-706 |
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| Authors: | CHEN Xin-ke PENG Hui LEI Bo WANG Juan FU Peng |
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| Affiliation: | CHEN Xin-ke,PENG Hui,LEI Bo,WANG Juan,FU Peng(Department Of Ophthalmology,the First Affiliated Hospital,Chongqing Medical University,Chongqing Key Laboratory of Ophthalmology) |
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| Abstract: | Objective: NSA2,a newly documented nuclear protein,plays an important role in cell proliferation.We investigated whether NSA2 is involved in the choroidal neovascularization(CNV),a common pathological process in many retinal diseases.Methods: CNV model was induced by 532 nm laser coagulation in 16 mice.Five days after laser photocoagulation,NSA2 mRNA level in the posterior segment of the eyes was detected by Real-time quantitative PCR.NSA2 expression in eyeballs was detected by immunofluorescence staining w... |
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| Keywords: | choroidal neovascularization animal model nucleoprotein |
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