| 固体脂质纳米姜黄素联合顺铂对卵巢癌SKOV3的增殖及Bax/Bcl-2蛋白表达的实验研究 |
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| 引用本文： | 邓舒婷,甘霖,周琦,徐建业,李少林. 固体脂质纳米姜黄素联合顺铂对卵巢癌SKOV3的增殖及Bax/Bcl-2蛋白表达的实验研究[J]. 重庆医科大学学报, 2011, 36(6): 650-653 |
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| 作者姓名： | 邓舒婷 甘霖 周琦 徐建业 李少林 |
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| 作者单位： | 1. 重庆医科大学基础医学院放射医学教研室,重庆,400016
2. 重庆市肿瘤研究所妇瘤科,重庆,400030 |
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| 基金项目： | 重庆市卫生局科研资助项目(编号:2007-2-68) |
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| 摘 要： | 目的:研究固体脂质纳米姜黄素(Curcumin-loaded solid lipid nanoparticles,SLN-Cur)与顺铂(Cisplatin,DDP)联用对人卵巢癌SKOV3细胞株生长的影响及促凋亡作用.方法:姜黄素(Curcumin,Cur)制备成SLN-Cur新型给药系统,分别检测DDP、Cur、S...
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| 关 键 词： | 固体脂质纳米粒 姜黄素 顺铂 人卵巢癌SKOV3细胞株 细胞凋亡 |
Effect of curcumin-loaded solid lipid nanoparticles and DDP on proliferation and expression of Bax/Bcl-2 protein in human ovarian cell line SKOV3 |
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| DENG Shu-ting,GAN Lin,ZHOU Qi,XU Jian-ye,Li Shao-lin. Effect of curcumin-loaded solid lipid nanoparticles and DDP on proliferation and expression of Bax/Bcl-2 protein in human ovarian cell line SKOV3[J]. Journal of Chongqing Medical University, 2011, 36(6): 650-653 |
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| Authors: | DENG Shu-ting GAN Lin ZHOU Qi XU Jian-ye Li Shao-lin |
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| Affiliation: | DENG Shu-ting1,GAN Lin2,ZHOU Qi1,XU Jian-ye2,Li Shao-lin1(1.Department of Radiation Medicine,College of Basic Medcine,Chongqing Medical University,2.Department of Gynecology,Chongqing Tumor Institue) |
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| Abstract: | Objective:To investigate the effect of curcumin-loaded solid lipid nanoparticles(SLN-Cur)in combination with cisplatin(DDP)on growth of human ovarian cancer cell line SKOV3 and its apoptosis induction.Methods:SLN-Cur was prepared in an aqueous system using curcumin as a model drug.SKOV3 cells were treated with curcumin,DDP,SLN-Cur,curcumin combined with DDP and SLN-Cur combined with DDP respectively.Cell morphology variation and cell ultrastructure were observed;the apoptosis rate of SKOV3 cell and the expr... |
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| Keywords: | solid lipid nanoparticles curcumin Cisplatin(DDP) human ovarian cancer cell line SKOV3 cell apoptosis |
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