| 汉黄芩素对肺癌细胞株A549的体外作用研究 |
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| 引用本文： | 李现东. 汉黄芩素对肺癌细胞株A549的体外作用研究[J]. 重庆医科大学学报, 2011, 36(7) |
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| 作者姓名： | 李现东 |
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| 作者单位： | 河南大学淮河医院呼吸科; |
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| 摘 要： | 目的:探讨体外汉黄芩素对肺癌细胞株A549增殖、侵袭及凋亡的影响。方法:应用MTT(噻唑蓝)法检测汉黄芩素对于A549细胞增殖活性;用形态学方法观察汉黄芩素对A549细胞的促凋亡作用;应用Transwell法观察细胞侵袭能力。结果:汉黄芩素对A549细胞增殖和侵袭活性具有明显抑制作用,对肺癌细胞有明显促凋亡作用,镜下可见染色体聚集及细胞核碎裂。结论:汉黄芩素对肺癌A549细胞的增殖迁移均有明显抑制作用并可促进肿瘤细胞凋亡。
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| 关 键 词： | 汉黄芩素 凋亡 |
Inhibitory effects of wogonin on lung cancer A549 cell line in vitro |
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| LI Xian-dong. Inhibitory effects of wogonin on lung cancer A549 cell line in vitro[J]. Journal of Chongqing Medical University, 2011, 36(7) |
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| Authors: | LI Xian-dong |
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| Affiliation: | LI Xian-dong(Department of Respiratory,Huaihe Hospital of Henan University) |
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| Abstract: | Objective:To study the inhibitory effect of wogonin on proliferation,invasion ability and pro-apoptotic activity in lung cancer A549 cell line.Methods:MTT chromatometry was employed to determine the influence of wogonin on proliferation of A549 cell.The apoptosis-promoting effect of wogonin on A549 cell was observed by morphological method.The changes of cell invasive ability in vitro were detected by Transwell assay.Results:Wogonin showed significant inhibitory effect on the proliferation and invasive acti... |
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| Keywords: | wogonin apoptosis |
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