| 微量稀释法检测氟康唑和伊曲康唑对白念珠菌的敏感性 |
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| 引用本文： | 贺志彬,廖万清,徐红,温海.微量稀释法检测氟康唑和伊曲康唑对白念珠菌的敏感性[J].中国中西医结合皮肤性病学杂志,2005,4(2):71-73. |
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| 作者姓名： | 贺志彬 廖万清 徐红 温海 |
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| 作者单位： | 1. 中国人民解放军第187医院皮肤科,海口,571159
2. 上海长征医院皮肤科,上海,200003 |
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| 摘 要： | 目的了解氟康唑和伊曲康唑对白念珠菌敏感性.方法采用NCCLS公布的M27-A方案微量稀释法,对19株白念珠菌临床分离株和3株标准株进行氟康唑和伊曲康唑药物的敏感性观测.结果19株临床分离株发现氟康唑耐药株7株,敏感株8株,剂量依赖的敏感菌株4株;伊曲康唑耐药株9株,敏感株8株,余2株为剂量依赖的敏感菌株;3株标准株结果符合.结论M27-A方案微量稀释法适合于临床检测白念珠菌的药物敏感性,氟康唑和伊曲康唑在白念珠菌中存在较高的耐药率和交叉耐药现象.
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| 关 键 词： | 白念珠菌 氟康唑 伊曲康唑 药物敏感性 |
| 文章编号： | 1672-0709(2005)02-0071-03 |
| 修稿时间： | 2004年11月22 |
Observing the Susceptibility of Candida Albicans Challenge with Fluconazole and Itraconazole by M27-A Microdilution Method |
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| HE Zhi-Bin,LIAO Wan-qing,XU Hong,WEN Hai.Observing the Susceptibility of Candida Albicans Challenge with Fluconazole and Itraconazole by M27-A Microdilution Method[J].Chinese J of Dermatovenerology Integr Tradit and West Med,2005,4(2):71-73. |
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| Authors: | HE Zhi-Bin LIAO Wan-qing XU Hong WEN Hai |
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| Abstract: | Objective To investigate the susceptibility of Candida albicans cultured with Fluconazole and Itraconazole. Methods M27-A microdilution method based on NCCLS was used to determined the susceptibility of 19 Candida albicans isolates and 4 ATCC cultured with Fluconazole and Itraconazole. Results 7 Fluconazole-resistance isolates, 8 susceptible isolates, 4 susceptible dose dependent(SDD) isolates, 9 Itraconazole-resistance isolates, 8 susceptible isolates, and 2 SDD isolates were detected from 19 clinical Candida albicans isolates. Conclusion It suggested that M27-A method based on NCCLS is suitable to examin the susceptibility of Candida albicans, and the obvious resistance to Fluconazole and Itraconazole of Candida albican and cross-resistance between Fluconazole and Itraconazole were found in this study. |
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| Keywords: | Candida albicans Fluconazole Itraconazole drug susceptibility |
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