Inhibitory effect of ethanol extract of Magnolia officinalis and 4-O-methylhonokiol on memory impairment and neuronal toxicity induced by beta-amyloid |
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Authors: | Jae Woong Lee Beom Jun Lee Sang Il Lee Ki Ho Kim Jin Tae Hong |
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Institution: | a College of Pharmacy, Core Research Institute, Chungbuk National University, 12, Gaesin-dong, Heungduk-gu, Cheongju, Chungbuk 361-763, Republic of Korea b College of Veterinary Medicine and Research Institute of Veterinary Medicine, Core Research Institute, Chungbuk National University, 12, Gaesin-dong, Heungduk-gu, Cheongju, Chungbuk 361-763, Republic of Korea c R&D Center, Bioland Ltd., Songjeong, Byongchon, Cheonan-Si, Chungnam 330-863, Republic of Korea |
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Abstract: | The components of the herb Magnolia officinalis have exhibited antioxidant and neuroprotective activities. In this study, we investigated effects of ethanol extract of M.officinalis and its major component 4-O-methylhonokiol on memory dysfunction and neuronal cell damages caused by Aβ. Oral pretreatment of ethanol extract of M. officinalis (2.5, 5 and 10 mg/kg) and 4-O-methylhonokiol (1 mg/kg) into drinking water for 5 weeks suppressed the intraventricular treatment of Aβ1-42 (0.5 μg/mouse, i.c.v.)-induced memory impairments. In addition, 4-O-methylhonokiol prevented the Aβ1-42-induced apoptotic cell death as well as β-secretase expression. 4-O-methylhonokiol also inhibited H2O2 and Aβ1-42-induced neurotoxicity in cultured neurons as well as PC12 cells by prevention of the reactive oxygen species generation. 4-O-methylhonokiol also directly inhibited β-secretase activity and Aβ fibrilization in vitro. Thus, ethanol extract of M. officinalis may be useful for prevention of the development or progression of AD, and 4-O-methylhonokiol may be a major active component. |
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Keywords: | Alzheimer`s disease Beta-amyloid peptide ROS Memory 4-O-methylhonokiol |
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