Pretreatment with l-histidine produces a shift from methamphetamine-induced stereotypical biting to persistent locomotion in mice |
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Authors: | Junichi Kitanaka Nobue Kitanaka Tomohiro Tatsuta Atena Koumoto Koh-ichi Tanaka Yoshio Morita |
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Affiliation: | a Department of Pharmacology, Hyogo College of Medicine, Hyogo 663-8501, Japan b Department of Neuropsychiatry, Hyogo College of Medicine, Hyogo 663-8501, Japan c Division of Pharmacology, Department of Pharmacy, School of Pharmacy, Hyogo University of Health Sciences, Hyogo 650-8530, Japan |
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Abstract: | The administration of methamphetamine (METH; 10 mg/kg, i.p.) to male ICR mice induced bizarre behaviors including persistent locomotion and stereotypical behaviors, which were classified into four categories: stereotypical head-bobbing, circling, sniffing, and biting. Pretreatment with l-histidine (750 mg/kg, i.p.) significantly decreased the stereotypical biting induced by METH and significantly increased persistent locomotion. This effect of l-histidine on behavior was completely abolished by simultaneous administration of pyrilamine or ketotifen (brain-penetrating histamine H1 receptor antagonists; 10 mg/kg each, i.p.), but not by the administration of fexofenadine (a non-sedating histamine H1 receptor antagonist that does not cross the blood-brain barrier; 20 mg/kg), zolantidine (a brain-penetrating histamine H2 receptor antagonist; 10 mg/kg), thioperamide, or clobenpropit (brain-penetrating histamine H3 receptor antagonists; 10 mg/kg each). The histamine content of the hypothalamus was significantly increased by l-histidine treatment. These data suggest that l-histidine modifies the effects of METH through central histamine H1 receptors. |
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Keywords: | Methamphetamine smallcaps" >l-Histidine Histaminergic neurotransmission Stereotypy Hypothalamus |
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