LC-MS/MS分子网络及其对中药研究的启发

近年来,LC-MS/MS的分子网络技术已广泛应用于微生物、海洋生物、真菌及植物等来源的天然产物的研究,关于分子网络在中药方面的研究应用却鲜有报道。以分子网络为主题,首先对分子网络进行简要介绍,并对分子网络方面的文献进行了调研;随后,对分子网络策略在化学成分定性表征、化学成分定量表征及质量控制、指导活性化合物的分离、提取工艺的优化以及疾病诊断和个性化治疗5个方面的应用进行综述;最后,对分子网络在中药研究方面的应用进行了展望,旨在为中药研究提供新的思路和方法,以期促进中医药的现代化发展。

LC-MS/MS-based molecular networking producing enlighten study of Chinese materia medica

Recently, LC-MS/MS-based molecular networking has been widely used in the field of natural products from microorganisms, marine organisms, fungi, plants, and so on, while there are few reports on the research and application of LC-MS/MS-based molecular networking in the field of Chinese materia medica (CMM). Covering molecular networking topic, what is molecular networking was firstly introduced and the literatures related to molecular networking was retrieved. Then the application of molecular networking on five aspects were reviewed, including qualitative characterization of components, quantitative characterization of components and quality control, guiding the active compounds separation, optimizing the extraction process and disease diagnosis as well as personalized treatment. In the end, this study forecasted the prospects of molecular networking in the field of CMM, aiming to provide new thought and methodology for the research of CMM and expect to expedite the development of traditional Chinese medicine.