microRNAs在溃疡性结肠炎中的研究进展

microRNAs（miRNAs）是长度为19—25个碱基的低聚寡核苷酸片段,通过与靶mRNA的3’端非翻译区完全或不完全配对结合,介导靶mRNA降解或抑制翻译。miRNAs广泛参与体内细胞增殖、分化、炎症、纤维化过程。溃疡性结肠炎（UC）是一种病因未明的慢性非特异性肠道炎症性疾病,目前研究发现miRNAs参与UC的发生、发展。本文就miRNAs在UC中的研究进展作一综述。

Research Advances of microRNAs in Ulcerative Colitis

microRNAs （miRNAs） is the oligonucleotide of 19-25 bases which can bind to complementary sequences in the 3 ＇ untranslated region of target mRNA with complete or incomplete ways, resulting in either degradation of the target mRNA or translational inhibition. It is considered to be involved in the regulative processes of proliferation, differentiation, inflammation and fibrosis. Ulcerative colitis （UC） is a chronic intestinal inflammatory disease and its etiology has not yet been clarified. Recent studies have shown that miRNAs plays an important role in the development of UC. This article reviewed the advances of miRNAs in UC.