| 抗鼠IL－1α、IL－6单抗对狼疮倾向NZB／W F1小鼠的免疫调节研究 |
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| 引用本文： | 刘文励,孙汉英,邵静芳,徐慧珍,路武,沈关心.抗鼠IL－1α、IL－6单抗对狼疮倾向NZB／W F1小鼠的免疫调节研究[J].现代免疫学,1996(5). |
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| 作者姓名： | 刘文励 孙汉英 邵静芳 徐慧珍 路武 沈关心 |
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| 作者单位： | 同济医科大学附属同济医院内科，同济医科大学免疫室 |
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| 基金项目： | 国家自然科学基金,湖北省自然科学基金 |
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| 摘 要： | 对狼疮倾向ＮＺＢ／ＷＦ１小鼠在４月龄时腹腔注射抗鼠ＩＬ－１α、抗ＩＬ－６单抗，每日１次１０μｇ×３ｄ，后每月１次×３次，１１月龄活杀，发现这样的剂量不能完全防治狼疮性肾炎，但可减轻蛋白尿，明显降低血清ＩＬ－１α水平，抑制腹腔巨噬细胞分泌ＩＬ－１α。对ＩＬ－６和ＴＮＦ－α水平无明显影响。
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| 关 键 词： | NZB／W F1小鼠，抗IL－1α，抗IL－6，免疫调节 |
Effects of Anti-murine IL-1α and IL-6 Monoclonal Antibodies on the Immunoregulation in Lupus-like NZB/W F1 Mice |
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| Liu Wenli, Sun Hanying, Shao Jingfang, Xu Huizhen, Lu Wu and Sheng Guanxin.Effects of Anti-murine IL-1α and IL-6 Monoclonal Antibodies on the Immunoregulation in Lupus-like NZB/W F1 Mice[J].Current Immunology,1996(5). |
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| Authors: | Liu Wenli Sun Hanying Shao Jingfang Xu Huizhen Lu Wu and Sheng Guanxin |
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| Abstract: | μg of anti-murine IL-1α、IL-6 monoclonal antibodies were intraperitonealy injected to the lupus-like NZB/W F1 mice of 4 months every day for three days and then every month for three months. The mice were killed at the age of 11 months. Experimental results showed that this dosage could not absolutely prevent lupus glomerulonephritis, it could lighten proteinuria, obviously reduce the level of serum IL-1α and inhibit the secretion of IL-1α by celiac macrophage. As to the level of IL-6 and TNF-α, no significant change was observed. |
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| Keywords: | NZB/W F1 mouse anti-IL-1α anti-IL-6 immunoregulation |
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