| 5-羟色胺2A受体与疼痛 |
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| 引用本文： | 冀海明,洪炎国.5-羟色胺2A受体与疼痛[J].国际病理科学与临床杂志,2007,27(5):20-460. |
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| 作者姓名： | 冀海明 洪炎国 |
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| 作者单位： | 福建师范大学生命科学学院人体解剖生理教研室,福建省发育和神经生物学重点实验室,福州,350108 |
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| 基金项目： | 国家自然科学基金(30570600)~~ |
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| 摘 要： | 5-羟色胺(5-HT)是一种内源性的活性物质,5-HT具有多种受体亚型。在中枢可以通过2A受体引起抑制性神经递质γ-丁氨酸（GABA ）等的释放，从而发挥镇痛作用；在外周参与伤害性感受器的活化,促进伤害性信息的传递。组织损伤以及炎症状态下,血小板和肥大细胞即释放5-HT。5-HT2A受体可介导5-HT引起的疼痛,该受体可以作为开发外周镇痛药物的重要靶点。
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| 关 键 词： | 5-羟色胺受体 外周 中枢 致痛 镇痛 |
| 收稿时间： | 2007-1-26 |
| 修稿时间： | 2007-5-21 |
5-hydroxytriptamine 2A receptor and pain |
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| JI Hai-ming,HONG Yan-guo.5-hydroxytriptamine 2A receptor and pain[J].Journal of International Pathology and Clinical Medicine,2007,27(5):20-460. |
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| Authors: | JI Hai-ming HONG Yan-guo |
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| Institution: | Department of Anatomy and Physiology, College of Life Sciences, Fujian Normal University,Key Laboratoryof Developmental and Neurological Biology of Fujian Province, Fuzhou 350108, China |
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| Abstract: | 5-hydroxytriptamine (5-HT) is an endogenous bioactive substance and its receptor has many subtypes including 5-HT2A. In the central, 5-HT can induce the release of inhibitory neurotransmitter γ-aminobutyric acid (GABA) etc. through 5-HT2A receptor resulting in analgesia. In the peripheral, 5-HT can active the nociceptor and advance the traumatic information transmission. 5-HT can be released from the platelets and mast cells under the injured and inflammatory conditions. The 5-HT2A receptor subtype is involved in the 5-HT-mediated nociceptive mechanism, which can be researched as a target in exploring peripheral antinociceptive medication. |
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| Keywords: | 5-HT2A receptor peripheral central nociception antinociception |
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