新生儿多器官功能障碍综合征的临床研究

目的了解危重新生儿多器官功能障碍的常见原发病及预后。方法回顾性分析188例危重新生儿的临床资料。结果全组188例危重儿,102例出现程度不等的器官功能损害,56例为多脏器功能障碍综合征(MODS),死亡17例,MODS病死率30.4%(17/56)。发生肺、心、脑、胃肠道、肾、肝及凝血系统方面功能障碍构成比为34.6%,19.4%,15.7%,13.1%,9.9%,6.3%,1.0%;1-5个器官功能障碍时病死率分别为2.2%,12.5%,43.8%,71.40.0%;窒息、缺氧缺血性脑病,吸入性肺炎,败血症者易发生MODS。结论MODS在NICU中发生率及病死率均高,预后与发生障碍器官的严重度、数目有关。

The clinical study on multiple organ dysfunction syndrome in neonates

Objective To explore the prognosis and the primary affection of multiple organ dysfunction syndrome(MODS) in newborns with serious disease.Methods 188 newborns with serious disease were analyzed retrospectively.Results Among 188 cases,there were 102 cases with organ impairment to various degrees,and 56 with developed MODS and 17 cases died(30.4%).The disfunction constituent ratio of pulmonary,cardiac,cerebral,gastro-intestinal,renal,hepatic,blood coagulation systems were 34.6%,19.4%,15.7%,13.1%,9.9%,6.3% and 1.0%,respectively.The mortality of neonate with one to five organs dysfunction was 2.2%,12.5%,43.8%,71.4% and 100%,respectively.Asphyxia,hypoxic ischemic encephalopathy,aspiration pneumonia and sepsis resulted in the MODS easily.Conclusion The morbidity and mortality of MODS in NICU is higher than those of any other diseases,and the prognosis is related with the severity of disfunction occurred and the number of organs involved.