小剂量红霉素治疗早产儿胃肠道功能紊乱

目的:评价小剂量红霉素治疗早产儿胃肠道功能紊乱的疗效。方法:将诊断明确的129例患儿随机分为治疗组65例,对照组64例,对照组予常规对症支持治疗,治疗组在常规处理基础上加用小剂量红霉素3~5mg/(kg·d)缓慢静脉滴注,1次/d,连用4~10d。结果:治疗组呕吐症状、胃潴留缓解以及奶量增加和体重增长有效率分别是83.1%、81.5%、73.8%、78.5%,均明显高于对照组(P<0.05),且无明显副作用。结论:小剂量红霉素治疗早产儿胃肠道功能紊乱安全有效,具有一定的临床价值。

A study on the therapy of small dose of erythromycin for the preterm infants with gastrointestinal dysfunction

Objective:To evaluate the clinical curative effect of a small dose of erythromycin(EM)for the preterm infants with gas-trointestinal dysfunction.Methods:129cases of gastrointestinal dysfunction were divided into two groups at random,EM group of65cas-es and control group,64cases.The control group was treated routinely.Besides routine therapy,EM groups were treated with intravenous erythromycin slowly dropping at a low dose of3~5mg/kg,once a day and for4~10days.Results:The effective rate of EM group is high-er than that of control group(P<0.05)in signs of vomiting mitigating(83.1%),stomach retention(81.5%),milk increasing(73.8%)and weight growing(78.5%).No significant adverse effects were observed.Conclusion:Low dose of erythromycin administration in the preterm infants with gastrointestinal dysfunction is a useful and safe treatment,which is of importance in clinical practice.