盐酸戊乙奎醚对老年患者腹腔镜胆囊切除术血流动力学的影响

目的 观察盐酸戊乙奎醚对老年患者腹腔镜胆囊切除手术血流动力学的影响.方法 选择择期行腹腔镜胆囊切除术患者40人,年龄65～80岁,随机分为两组：盐酸戊乙奎醚组（PHC组）和对照组（Con组）.PHC组气腹前半小时给予盐酸戊乙奎醚0.5 mg肌肉注射,对照组同一时间点予肌肉注射生理盐水0.5ml.分别记录基础值、牵拉胆囊时、气腹10分钟时和消气腹后30分钟SBp、DBp及HR值,并行统计学分析.结果 两组SBp、DBp在牵拉胆囊时均有下降,HR均有减慢,气腹10分钟时SBp、DBp均有升高,HR均有增快,但盐酸戊乙奎醚组与对照组相比变化的幅度均较小,两组相比差异有统计学意义.与基础值相比,盐酸戊乙奎醚组在牵拉胆囊时、气腹10分钟时各值变化均无统计学意义,对照组差异有统计学意义.消气腹后30分钟两组患者的SBp、DBp及HR值均有恢复,与基础值相比、两组相比差异均无统计学意义.结论 盐酸戊乙奎醚用于老年人腹腔镜手术可有效防止血流动力学剧烈波动,从而提高手术安全性.

Hemodynamic effects on elderly patients with laparoscopic cholecystectomy by using Penehyclidine Hydrochloride

Objective To observe the hemodynamic effects on elderly patients with laparoscopic choleeysteetomy by Penehyclidine Hydrochloride. Methods Selected 40 laparoscopic cholecystectomy patients who were 65 - 80 years old, which randomly divided into 2 groups ： Penehyelidine Hydrochloride group （ group PHC ） and control group （group Con）. PHC group given to be muscle injected with 0. 5 mg Penehyclidine Hydrochloride at half an hour before pneumoperitoneum, the control group was given to be muscle injected with 0.5 ml saline solution at the same time. Recorded the SBP, DBP, and HR value of the base values, at the time of pulling gallbladder, 10 minutes after pneumoperitoneum and 30 minutes after eliminating pneumoperitoneum. And then to do statistical analysis. Results The SBP, DBP of two groups were falling and the HR of two groups was slowing when the gallbladder were pulled. The SBP and DBP of two group were elevating and the HR of two group was increasing quickly at 10 minutes after Pneumoperitoneum. But comparing to the control group, the variational range of group PHC were smaller at the same time point. The difference of two groups was statistically significant. Compared to the basic values, the value changes of group PHC were not statistically significant when the gallbladder were pulled or at 10 minutes after Pneumoperitoneum, but the difference which of the control group was statistically significant. The SBP, DBP and HR of two groups were recovered at 30 minutes after eliminating pneumoperitoneum. There were no statistically significant difference neither comparing to the base values nor comparing with the two groups. Conclusions Penehyclidine Hydrochloride used to the elderly patients with laparoseopic cholecystectomy can effectively prevent the hemodynamics variations, and improve operation safety.