地佐辛与芬太尼用于神经外科患者术后自控静脉镇痛的比较

目的 观察地佐辛与芬太尼用于神经外科患者术后自控静脉镇痛的效果及不良反应.方法 80名行神经外科手术的患者被随机分成芬太尼镇痛组（Ⅰ组,n=40）和地佐辛镇痛组（Ⅱ组,n=40）.Ⅰ组PCIA采用芬太尼16 μg/kg、雷莫司琼0.6 mg;Ⅱ组PCIA采用地佐辛0.8 mg/kg、雷莫司琼0.6 mg.观察并记录两组患者使用PCIA后2、6、12、24、48h镇痛、镇静效果及不良反应情况.结果两组患者镇痛镇静效果无统计学差异（P＞0.05）,不良反应发生率差异有统计学意义（P＜0.05）.结论0.8 mg/kg的地佐辛可以安全有效的应用于神经外科患者术后自控静脉镇痛.

Comparison of the analgesic effects of dezocine and fentanyl on patient controlled intravenous analgesia

Objective To observe the analgesic effects and adverse reactions of dezocine and fentanyl on patient controlled intravenous analgesia. Methods 80 patients suffered military surgery under general anesthesia were divided into fentanyl group （ group I, n = 40） and dezocine group （group II, n = 40） randomly. The PCIA solution contained fentanyl （16p~g/kg） and dezocine （0.8mg/kg） on the basis of ramosetmn （0.6mg） for group I and group II respectively. Observed and record the adverse and analgesic effects at the time point 2, 4, 12, 24, 48h after the patients received PCIA. Results The analgesic effects of the two groups present no significantly difference （ P 〉 0.05 ）, however, the incidence of adverse effects of the two groups present significantly difference （P 〈 0. 05 ）. Conclusions Dezocine. at the dose of 0.8mz/k~. is safe and effective for PCIA.