重复经颅磁刺激治疗老年精神分裂症顽固性幻听的临床疗效观察

目的 分析低频重复经颅磁刺激治疗老年精神分裂症顽固性幻听临床疗效,旨在为老年精神分裂症顽固性幻听治疗提供新的手段.方法 选取我院2009年1月至2013年3月收治的98例老年精神分裂症患者为研究对象.应用随机数字表法将老年精神分裂症患者分为两组,观察组患者接受利培酮联合低频重复经颅磁刺激治疗,对照组患者则仅接受利培酮治疗.采用AHRS听幻觉量表和副反应量表（TESS）对老年精神分裂症患者进行测评,测评时间选择在治疗前和治疗2个月后,比较两组患者AHRS听幻觉量表和副反应量表（TESS）得分差异.结果 治疗2个月后,观察组幻听评分低于对照组幻听评分,差异有统计学意义（P〈0.05）,观察组患者不良反应未见明显增加,差异无统计学意义（χ2=0.154,P〉0.05）.结论 低频重复经颅磁刺激精神分裂症左侧颞顶叶能够显著改善老年精神分裂症患者顽固性幻听,具有安全高效和不良反应少等特点,值得在老年精神分裂症顽固性幻听中推广应用.

Clinic effect observation on repetitive transcranial magnetic stimulation in treatment of senile schizophrenia obstinate auditory hallucinations

Objective To analyze the low frequency repetitive transeranial magnetic stimulation in the treatment of senile schizophrenia clinical efficacy in refractory auditory hallucinations, aim to provide new means for the treatment of senile schizophrenia obstinate auditory hallucinations. Methods In our hospital, from January, 2009 to March, 2013, 98 cases of senile schizophrenia patients were treated as the research object. Application of the method of random digits table of elderly schizophrenic patients were divided into two groups, the observation group patients received risperidone combined with low frequency repetitive transcranial magnetic stimulation therapy, patients in the control group only received risperidone in the treatment of. Using AHRS auditory hallucinations scale and Treatment Emergent Symptom Scale （TESS） evaluation of senile schizophrenia patients, evaluation time choice of treatment and 2 months before treatment, compared two groups of patients with AHRS auditory hallucinations scale and Treatment Emergent Symptom Scale （TESS） score difference. Results After 2 month treatment, the observation group was lower than that of the control group hallucination auditory hallucinations score, the difference was statistically significant （ P 〈 O. 05）, patients in the observation group with no obvious adverse reactions, no significant difference （ ~2 = 0. 154, P 〉 0. 05 ）. Conclusions Low-frequency repetitive transcranial magnetic stimulation of the left temporal lobe in schizophrenia can significantly improve the elderly spiritual refractory schizophrenic patients with auditory hallucination, safety and high efficiency and few adverse reactions, it is worthy of popularization and application in senile schizophrenia obstinate auditory hallucinations.