CEACAM1 loss links inflammation to insulin resistance in obesity and non-alcoholic steatohepatitis (NASH) |
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Authors: | Sonia M. Najjar Lucia Russo |
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Affiliation: | 1. Center for Diabetes and Endocrine Research, University of Toledo, Health Science Campus, 3000 Arlington Avenue, Mail stop 1009, Toledo, OH, 43614, USA 2. Department of Physiology and Pharmacology, College of Medicine and life Sciences, University of Toledo, Health Science Campus, 3000 Arlington Avenue, Mail stop 1009, Toledo, OH, 43614, USA
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Abstract: | Mounting epidemiological evidence points to an association between metabolic syndrome and non-alcoholic steatohepatitis (NASH), an increasingly recognized new epidemic. NASH pathologies include hepatocellular ballooning, lobular inflammation, hepatocellular injury, apoptosis, and hepatic fibrosis. We will review the relationship between insulin resistance and inflammation in visceral obesity and NASH in an attempt to shed more light on the pathogenesis of these major metabolic diseases. Moreover, we will identify loss of the carcinoembryonic antigen-related cell adhesion molecule 1 as a unifying mechanism linking the immunological and metabolic abnormalities in NASH. |
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