| AG490对人外周血NK细胞活性及淋巴细胞转化功能的影响 |
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| 引用本文： | 王蓉,张平,等.AG490对人外周血NK细胞活性及淋巴细胞转化功能的影响[J].华西医科大学学报,2001,32(2):219-221. |
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| 作者姓名： | 王蓉 张平 |
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| 摘 要： | 目的 研究AG490对正常人外周血NK细胞杀伤活性及淋巴细胞转化功能的影响。方法 采用体外实验，MTT比色法检测细胞存活、NK细胞杀伤活性及细胞增殖情况。结果 AG490能抑制IL－2及PHA诱导外周血单核细胞增殖的作用，并抑制NK细胞杀伤活性。结论 AG490作为一种酪氨酸激酶抑制剂，能影响正常细胞的功能。
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| 关 键 词： | AG490 NK细胞活性 淋巴细胞转化功能 白细胞介素2 |
The effect of AG490 on NK activity and lymphocyte transformation of PBMC] |
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| R Wang,P Zhang,D Wei,Z Zhao.The effect of AG490 on NK activity and lymphocyte transformation of PBMC][J].Journal of West China University of Medical Sciences,2001,32(2):219-221. |
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| Authors: | R Wang P Zhang D Wei Z Zhao |
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| Institution: | Department of Immunology, School of Basic Medical Sciences, WCUMS, Chengdu 610041, China. |
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| Abstract: | OBJECTIVE: To examine the effect of AG490 on NK activity and lymphocyte transformation. METHODS: Using MTT colorimetry to detect cell survival, NK activity and cell proliferation. RESULTS: AG490 inhibited IL-2 and PHA induced peripheral blood mononuclear cell proliferation, and it inhibited NK activation. CONCLUSION: As an inhibitor of JAK, AG490 can influence the function of normal cells. |
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