渗出性胸腔积液柯萨奇病毒B抗体的检测

目的 :明确柯萨奇病毒所致胸膜感染的发病情况及其胸液特征。方法 :应用间接酶联免疫吸附试验(ELISA)检测 131例良性渗出性胸腔积液患者血清和 或胸液中柯萨奇病毒B抗体。结果 :131例良性渗出性胸腔积液患者 ,11例检测出柯萨奇病毒B抗体 ,其中有 4例仅在胸液中检测出柯萨奇病毒B抗体 (IgG阳性 1例 ,IgM阳性3例 ) ,5例在血清中检测出柯萨奇病毒B抗体 (IgG阳性 4例 ,IgM阳性 1例 ) ,2例在胸液及血清中均检测出柯萨奇病毒BIgM。与柯萨奇病毒B抗体阴性、诊断为结核性胸腔积液的患者胸液相比 ,柯萨奇病毒B抗体阳性的渗出性胸液患者的胸液并无显著性特征。结论 :柯萨奇病毒B感染确实可致胸腔积液。由于胸液无显著性特征 ,病毒性胸腔积液极易和结核性胸腔积液相混淆

Detection of Antibodies of Coxsackie Virus in Patients with Exudative Effusion

Objective:To determine the incidence of pleural infection caused by Coxsackie virus and the feature of its pleural fluid. Methods: The serum and/or pleural effusion antibodies of Coxsackie virus type B in 131 patients with benign exutrate were detected by indirect enzyme linked immunoabsorbent assay(ELISA). Results: Coxsackie virus antibodies were found in 11 out of 131 cases with benign exudative effusion. Four cases of them gained positive results in pleural effusion (1 case for IgG, 3 for IgM), 5 cases in serum (4 cases for IgG, 1 for IgM), and 2 cases were positive for IgM in both pleural effusion and serum. Compared with those negative for Coxsackie virus antibodies,which were diagnosised as tuberculous pleural effusion. The positive patients had no significant feature in their pleural fluid. Conclusions: Coxsackie virus can indeed infect pleura and cause pleural effusion. Virual pleural fluid can easily confused with tuberculous pleural effusion.