| 垂体后叶素对门脉高压性胃病胃粘膜灌注的影响 |
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| 引用本文： | 乐桥良,张贤康,张兴荣. 垂体后叶素对门脉高压性胃病胃粘膜灌注的影响[J]. 胃肠病学和肝病学杂志, 2000, 9(3): 194-196 |
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| 作者姓名： | 乐桥良 张贤康 张兴荣 |
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| 作者单位： | 1. 南京军区福州总医院消化内科,福州市,350025
2. 第二军医大学长征医院消化内科 |
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| 摘 要： | 目的 探讨垂体后叶素对门脉高压性胃病（ＰＨＧ）大鼠胃粘膜血流量（ＧＭＢＦ）和血浆胰高粘素的影响。方法 部分结扎大鼠门脉主干２ｗｋ后，采用激光多普勒血流计（ＬＤＦ）测定大鼠ＧＭＢＦ，观察了垂体后叶素输注前和输注后３０ｍｉｎ ＧＭＢＦ，门脉压力（ＰＶＰ）的变化；测定了输注垂体后叶素３０ｍｉｎ后血浆胰高糖素的含量。结果 输注垂体后叶素１０ｍｉｎ ＰＨＧ大鼠的ＧＭＢＦ开始降低（Ｐ〈０．０５），１５ｍｉｎ显
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| 关 键 词： | 门脉高压性胃病 胃粘膜血流量 垂体后叶素 |
| 修稿时间： | 1999-09-15 |
Effects of vasopressin on gastric mucosal perfusion in rats with portal hypertensive gastropathy |
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| Le Qiaoliang,Zhang Xiankang,Zhang Xingrong. Effects of vasopressin on gastric mucosal perfusion in rats with portal hypertensive gastropathy[J]. Chinese Journal of Gastroenterology and Hepatology, 2000, 9(3): 194-196 |
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| Authors: | Le Qiaoliang Zhang Xiankang Zhang Xingrong |
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| Abstract: | Aim To observe the effects of vasopressin on gastric mucosal blood flow(GMBF)and plasma glucagon level in rats with portal hypertensive gastropathy(PHG). Methods Two weeks after portal vein ligation, GMBF was assessed by laser Doppler flowetry, the changes of GMBF and PVP were observed before and 30min after intravenous administration of vaso- pressin,plasma glucagon were tested 30min after intravenous administration of vasopressin or saline.Results GMBF were reduced 10min (P < 0.05) and 15min (P < 0.01 ) after intravenous propranolol, vasopressin administration significantly decreased PVP(P < 0.01 ), but had no effect on plasma glucapn(P < 0.05 ). Conclusion Vasopressin educed GMBF of rats with PHG, and had no effect on plasma glucagon. |
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| Keywords: | Portal hypertensive gastropathy Gastric mucosal blood flow Vasopressin |
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