磁共振feature tracking初步评价终末期肾病患者心肌形变

目的 采用心脏磁共振feature tracking (CMR-FT)技术初步分析终末期肾病患者左心室心肌形变各参数的变化情况。方法 对10例正常志愿者和9例终末期肾病接受血液透析治疗的患者行1.5T心脏非对比增强、FIESTA序列电影成像,并采用feature tracking (FT) 2D模型对左心室运动及整体心肌形变情况进行定量分析。结果 终末期肾病患者左心室心肌质量[(132.70±44.44) g]大于正常志愿者[(80.00±11.29)g, P<0.05]。终末期肾病患者左心室心肌整体径向应变、环向应变、径向收缩期峰值运动速度、径向舒张期峰值运动速度均低于健康志愿者[(22.52±10.41)% vs (39.46±7.10)%,(-12.57±3.91)% vs (-19.80±2.11)%,(22.70±5.72)mm/s vs (34.77±3.81)mm/s, (-24.71±8.83)mm/s vs (-43.88±8.89)mm/s, P均<0.05)。而终末期肾病患者和正常志愿者的左心室射血分数、左心室舒张末期容积、左心室收缩末期容积差异无统计学意义(P均>0.05)。结论 CMR-FT技术能够定量评价终末期肾病患者左心室心肌运动及形变情况。

MR feature tracking in preliminarily assessment on myocardial deformation in patients with end-stage renal disease

Objective To preliminarily assess left ventricular myocardial deformation using cardiac magnetic resonance feature tracking (CMR-FT) in patients with end-stage renal disease (ESRD). Methods Totally 10 healthy volunteers and 9 patients with ESRD underwent cardiac non-contrast cine imaging with FIESTA sequence on 1.5T MRI scan. Left ventricular myocardial deformation and motion were quantitatively evaluated by 2D-mode. Results The left ventricular mass in patients with ESRD ([132.70±44.44]g) was higher than that in healthy group ([80.00±11.29]g, P<0.05). Global peak radial strain, peak circumferential strain, radial systolic velocity, radial diastolic velocity of left ventricular myocardium in patients with ESRD were lower than them in healthy volunteers ([22.52±10.41]% vs[39.46±7.10]%,[-12.57±3.91]% vs[-19.80±2.11]%,[22.70±5.72]mm/s vs[34.77±3.81]mm/s,[-24.71±8.83]mm/s vs[-43.88±8.89]mm/s, all P<0.05). But, the other left ventricular function parameters, such as left ventricular ejection fraction (LVEF), left ventricular end-diastolic volume (LVEDV) and left ventricular end-systolic volume (LVESV) had no difference between patients with ESRD and healthy volunteers (all P>0.05). Conclusion CMR-FT could quantitatively evaluate left ventricular myocardial motion and deformation in patients with ESRD.