320排CT全脑灌注成像不同输入动脉对急性脑梗死灌注参数的影响

目的 探讨320排CT全脑灌注成像图像后处理中选择不同输入动脉对急性脑梗死患者灌注参数的影响。方法 回顾性分析40例单侧急性脑梗死患者(梗死组)及20例正常组320排CT全脑灌注成像数据,每例数据进行4次图像后处理,分别选择大脑前动脉、左侧(正常组)或患侧(梗死组)大脑中动脉、右侧(正常组)或健侧(梗死组)大脑中动脉及基底动脉作为输入动脉,4次图像后处理均选择上矢状窦作为输出静脉。分别在双侧大脑前动脉供血区、大脑中动脉供血区、大脑后动脉供血区绘制ROI,梗死组额外在梗死边缘正常侧、梗死边缘梗死侧绘制ROI,测量4次全脑灌注成像各ROI的局部脑血流量(rCBF)、局部脑血容量(rCBV)、平均通过时间(MTT)及达峰时间(TTP),取单侧大脑前动脉供血区、大脑中动脉供血区、大脑后动脉供血区灌注参数平均值作为该侧灌注参数值,对4次测量所获灌注参数数据进行单因素方差分析。结果 正常组4次不同输入动脉全脑灌注成像左、右侧大脑各灌注参数间差异均无统计学意义(P均>0.05)。梗死组4次不同输入动脉全脑灌注成像健侧、患侧大脑及梗死边缘正常侧、梗死侧各灌注参数之间差异均无统计学意义(P均>0.05)。结论 选择不同输入动脉对急性脑梗死患者CT全脑灌注成像参数的影响无统计学差异,在进行CT全脑灌注成像后处理时,可以选择显示较好的任意大脑动脉作为输入动脉。

Influence of different input artery on whole-brain CT perfusion parameters with 320-detector row CT in acute cerebral infarction

Objective To explore the influence of different input arteries in the reconstruction of CT perfusion imaging on whole-brain CT perfusion parameters with 320-detector row CT in acute cerebral infarction. Methods The whole-brain CT perfusion parameters of 20 normal patients and 40 patients with early unilateral cerebral infarction were retrospectively analyzed. In the reconstruction of whole-brain CT perfusion, every data was reconstructed 4 times and the anterior cerebral artery (ACA), left (normal) or injured side (infarction patients) middle cerebral artery (MCA), right (normal) or uninjured side (infarction patients) middle cerebral artery, basilar artery (BA) were chosen to be input artery respectively, and superior sagittal sinus were chosen to be output vein. ROI in the ACA, MCA, and posterior cerebral artery (PCA) territories of each side were drawn, ROI in the normal side and infarction side of the border of infarction in infarction patients extra were drawn. And cerebral blood flow (CBF), cerebral blood volume (CBV), mean transit time (MTT) and time to peak (TTP) of ROI were recorded.The average value of ROI in each side ACA, MCA and PCA territories standed for unilateral brain value. Four data were analyzed with one-factor analysis of variance. Results There was no statistical difference of all parameters among different input arteries in the normal patients (P>0.05). There was no statistical difference of all parameters among different input arteries in injured side and uninjured side brain, normal side and infarction side of the border of infarction parameters in infarction patients (P>0.05). Conclusion There is no statistical difference of whole-brain CT perfusion parameters among input different arteries in acute cerebral infarction.In the reconstruction of whole-brain CT perfusion, any large artery displayed well can be chosen as input artery.