K-ras and p53 point mutations in 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced hamster lung tumors |
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| Authors: | Oreffo, Victor I.C. Lin, Hsiu-Wei Padmanabhan, Rajini Witschi, Hanspeter |
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| Affiliation: | Institute of Toxicology and Environmental Health Davis, CA 95616, USA
1Division of Pulmonary/Critical Care Medicine, Department of Internal Medicine, University of California Davis, CA 95616, USA |
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| Abstract: | Lung tumors were induced in Syrian golden hamsters by s.c. injectionof 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK). After40 weeks lung tumor tissue was isolated. Administration of theNNK and exposure of the animals to an atmosphere of 65% oxygenresulted in a statistically significant reduction in tumor sizebut did not alter the histological tumor type or tumor incidencewhen compared with carcinogen treated animals maintained underambient air. Histologically, lung tumors had the morphologicfeatures of adenomas and adenocarcinomas with |
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