Drug inhibition indicates a single-site model of the 5-HT uptake site/antidepressant binding site in rat and human brain |
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Authors: | Jan O Marcusson Anna Andersson Inger Bäckström |
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Institution: | (1) Department of Geriatric Medicine, University of Umeå, S-901 87 Umeå, Sweden |
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Abstract: | Drug inhibition against 3H]paroxetine binding to rat cortex and human putamen was investigated in saturation experiments. The addition of 5-HT, imipramine, citalopram and clomipramine all produced changes in apparent binding affinity (Kd) without changes in the number of binding sites (Bmax). These data suggest that there is no heterogeneity of specific 3H]paroxetine binding, supporting a single site model of the 5-HT uptake site and antidepressant binding site. |
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Keywords: | [3H]paroxetine binding Rat cortex Human putamen Drug inhibition Homogeneity |
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