冠心病患者血清视黄醇结合蛋白4与高敏C反应蛋白的相关性分析

目的 测定冠心病患者血清视黄醇结合蛋白4（RBP4）和高敏C反应蛋白（hs-CRP）水平,分析两者与冠心病的相关性.方法 将90例冠心病患者分为急性心肌梗死组30例,不稳定性心绞痛组30例,稳定性心绞痛组30例,另选择30例冠状动脉造影结果正常者为对照组.采用酶联免疫吸附法测定受试者血清RBP4水平,采用增强免疫透射比浊法测定血清hs-CRP水平.结果 急性心肌梗死和不稳定性心绞痛组患者血清RBP4、hs-CRP水平高于稳定性心绞痛组和对照组,差异具有统计学意义（P〈0.05）,稳定性心绞痛组血清hs-CRP水平与对照组比较,差异有统计学意义（P〈0.05）,而稳定性心绞痛组患者血清RBP4水平与对照组比较差异尤统计学意义.单支、双支、三支病变组患者血清RBP4、hs-cRP水平均高于对照组（P〈0.05）,但单支、双支与三支病变组之间比较差异均无统计学意义.经Pearson＇s相关分析,冠心病患者血清RBP4与hs-CRP的浓度呈显著正相关（r=0.469,P〈0.01）.结论 血清RBP4、hs-CRP与冠心病存在一定的相关性,可能与斑块稳定性有关,可作为预测斑块稳定性的血清标志物,但其并不能反映冠状动脉狭窄程度及范围.

Study of the relationship between serum retinol binding protein 4 and high sensitive C-reactive protein in patients with coronary heart disease

Objective To evaluate the correlation of Retinol binding protein 4 （ RBP4）, the high sensitivity C-reactive protein（hs-CRP） and coronary heart disease（CHD） by test the serum level of them. Methods Ninety patients with CHD were divided into the acute myocardial infarction（AMl）group（n = 30 ）, the unstable angina pectoris （UAP） group （ n = 30 ） and the stable angina pectoris （SAP） group （ n = 30） ,30 normal subjects without CHD diagnosed by coronary arteriography （CAG） served as the control group. The serum level of RBP4 is measured by enzyme linked immune sorbent assay（ELISA） and the serum level of hs-CRP is measured by turbidmetricimmunoassay. Results The serum level of RBP4 and hs- CRP were higher in AMI and UAP group that in SAP group and control group（ P 〈0.05 ）. The mean level of hs-CRP in SAP group was differently significantly,compared with that in control（P 〉0.05）. While the RBP4 is the opposite. The mean level of RBP4 or hs-CRP in single, double and three vessel lesion group were higher than that in control group（ P 〈 0. 05 ）, but the serum levels of RBP4 or hs-CRP among single, double and three were not significant different（ P 〉 0.05 ）. The serum level of RBP4 and hs-CRP were significantly positive correlation in Spearman correlation coefficients （ r = 0. 469, P 〈 0.01 ）. Conclusions RBP4 and hs-CRP may act as one of vulnerable plaques, and be correlated with CHD. However, may not reflect the severity of artery stenosiso.