度洛西汀与帕罗西汀治疗不同症状抑郁症对照研究

目的 评价度洛西汀与帕罗西汀治疗不同症状抑郁症的临床疗效和安全性.方法 将88例抑郁症患者中,以精神症状为主诉者设为A组(46例),以躯体症状为主诉者设为B组(42例);将A组随机分为度洛西汀A组与帕罗西汀A组各23例;B组随机分为度洛西汀B组与帕罗西汀B组各21例,分别口服度洛西汀与帕罗西汀治疗,观察8周.于治疗前及...

A control study of duloxetine vs.paroxetine in the treatment of depression with different symptoms

Objective To evaluate the clinical efficacy and safety of duloxetine vs. paroxetine in the treatment of depression with different symptoms. Methods Eighty-eight depression patients were assigned to group A complaining of mental symptoms （n=46） and group 13 of physical symptoms （n=42）; group A was randomly assigned to duloxetine and paroxetine A （both n= 23）; group B was randomly assigned to duloxetine and paroxetine B （both n=21）; they took orally duloxetine or paroxetine for 8 weeks. Clinical efficacies were assessed with the Hamilton Depression Scale （HAMD） and adverse reactions with the Treatment Emergent Symptom Scale （TESS） before treatment and at the end of the 2^nd, 4^th, 6^th and 8^th week. Results After treatment, the HAMD scores of all groups lowered more significantly compared with pretreatment （P〈0.01）, decreased score continously heightened along with treatment; the HAMD scores in all peroids after treatment lowered more significantly （P〈0.01） and decreased score heightened （P〈 0.01） in the duloxetine than in the paroxetine B. At the end of the 8^th week, effective rates were 82.61% in the duloxetine A and 85.71% in the B and 78. 26% in the paroxetine A and 71.43% in the B,respectively. The effective rate was higher in the duloxetine than in the paroxetine B, but difference was not significant （Х^2= 1. 273, P〉0.05）. Adbverse reactions of both groups were mild,mainly headache, dizzness, nausea and so on, emerged in the initial stage of treatment more and lessoned or relieved gradually with treatment. Conclusion Both duloxetine and paroxetine have a notable curative effect, higher safety and better compliance in depression, but the former has an advantage over the latter in the treatment of depression accompanied with physical symptoms, and deserves to be spreaded and utilized clinically.