不同超前镇痛时点应用帕瑞昔布钠对妇科手术后的镇痛效果

目的 观察与比较不同超前镇痛时点应用帕瑞昔布钠对妇科手术后镇痛的作用效果.方法 将60例ASA Ⅰ或Ⅱ级择期妇科手术患者随机分为A、B两组,A组分别于麻醉诱导前10 min以及术后12h静脉注射帕瑞昔布钠40mg,而B组于手术结束时以及术后12h静脉给予帕瑞昔布钠40mg.两组患者术后均采用芬太尼进行患者自控静脉镇痛(PCA).观察术后12和24h患者PCA的总按压次数和PCA有效按压次数、术后2、4、6、12和24 h的疼痛强度(VAS评分)、满意程度(BCS评分)、镇痛的补救措施以及相关不良反应.结果 与B组比较,A组术后12和24 hPCA总按压次数和PCA有效按压次数降低(P＜0.05),术后2、4、6和12 h的VAS评分降低而BCS评分提高(P＜0.05),而两组24 h疼痛强度和满意度以及有关不良反应发生率差异尤统计学意义.结论 妇科手术超前应用帕瑞昔布钠,能减少术后芬太尼的用量,提高镇痛质量.

The analgesic efficacy of preoperative versus postoperative parecoxib in gynecologic surgery

Objective To compare the analgesic efficacy of preoperative or postoperative parecoxib administration in gynecologic surgery.MethodsSixty patients scheduled for gynecologic surgery were randomized into two groups.Group A:parecoxib 40 mg were intravenous 10 min before anesthesia and 12 hours postoperation.Group B:parecoxib 40 mg were intravenous at end of operation and 12 hours postoperation.Patients-control analgesia(PCA)with intravenous fentanyl.were used in both groups.Visual analog scale(VAS)score and Br...