艾司西酞普兰与氟西汀治疗老年抑郁症对照研究

目的 评价艾司西酞普兰治疗老年抑郁症的疗效与安全性.方法 将64例老年抑郁症患者随机分为两组,每组32例,研究组口服艾司西酞普兰治疗,对照组口服氟西汀治疗,观察6周.于治疗前及治疗第2周、4周、6周末采用汉密顿抑郁量表评定临床疗效,副反应量表评定不良反应.结果 治疗后两组汉密顿抑郁量表评分均较治疗前显著下降(P＜0.01);研究组治疗2周末较对照组下降更显著(P＜0.05).治疗6周末,研究组有效率81.3%,对照组为78.1%,两组差异无显著性(χ2=2.72,P＞0.05);两组不良反应均轻微,主要表现为恶心、呕吐等消化系统症状,发生率差异无显著性(P＞0.05).结论 艾司西酞普兰治疗老年抑郁症疗效显著,与氟西汀相当,安全性高,但艾司西酞普兰起效更快,可作为治疗老年抑郁症首选药物.

A control study of escitalopram vs.fluoxetine in the treatment of senile depression

Objective To evaluate the efficacy and safety of escitalopram in the treatment of senile depression. Methods Sixty-four senile depression patients were randomly assigned to two groups of 32 ones each, research group took orally escitalopram and control group did fluoxetine for 6 weeks. Clinical efficacies were assessed with the Hamiltion Depression Scale （HAMD） and adverse reactions with the Treatment Emergent Symptom Scale （TESS） before treatment and at the end of the 2^nd, 4^th and 6^th week. Results After 6 treatment, the HAMD scores of both groups lowered more significantly compared with pretreatment （P〈0.01） ; the HAMD score at the ned of the 2^nd week lowered more significantly in the research than m the control group （P〈0.05）. At the end of the 6^th week, effective rates were respectively 81.3% in the research and 78.1% in the control group, which showed no significant difference （Х^2=2.72, P〉0.05）; adverse reactions of both groups were mild and mainly digestive symptoms such as nausea, vomiting and so on, and there was no difference in incidence between 2 groups （P〉0.05）. Conclusion Escitalopram has a notable efficacy equivalent to fluoxetine and higher safety in senile depression,but the former takes effect more rapidly and can be used as the drug of choice for treating senile depression.