| 曲马多对胃肠道肿瘤患者术中免疫功能的影响 |
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| 引用本文： | 吴树宁,丁汉琳,李明强,周立文,雷成明.曲马多对胃肠道肿瘤患者术中免疫功能的影响[J].临床麻醉学杂志,2011,27(1). |
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| 作者姓名： | 吴树宁 丁汉琳 李明强 周立文 雷成明 |
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| 作者单位： | 华中科技大学同济医学院附属襄樊医院麻醉科,襄樊市,441021 |
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| 摘 要： | 目的 观察曲马多对胃肠道肿瘤患者术中T淋巴细胞亚群和NK细胞数量的影响.方法 30例胃肠道肿瘤行根治手术的患者随机均分为观察组和对照组.观察组麻醉前肌注曲马多1 mg/kg,对照组不使用.于麻醉前、手术1 h和术毕抽取外周静脉血,用流式细胞仪检测T淋巴细胞亚群(CD3+、CD3+CD4+、CD3+CD8+)、活化T细胞(CD3+HLA-DR+)和自然杀伤(NK)细胞(CD3-CDl6+CD56+)数量的变化.结果 两组手术1 h CD3+、CD3+CD4+、CD3+CD4+、CD3+CD8+、CD3+HLA-DR+和NK细胞数量均较麻醉前明显下降,对照组明显低于观察组(P＜0.05);术毕两组各指标有所回升,但对照组仍明显低于麻醉前水平和观察组(P＜0.05).结论 曲马多可减轻胃肠道肿瘤患者术中T淋巴亚群和NK细胞下降的程度,明显改善机体细胞免疫功能的抑制.
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| 关 键 词： | 曲马多 胃肠道肿瘤 T淋巴细胞亚群 NK细胞 |
Effects of tramadol on immune function in gastrointestinal cancer patients |
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| WU Shu-ning,DING Han-lin,LI Ming-qiang,et al..Effects of tramadol on immune function in gastrointestinal cancer patients[J].The Journal of Clinical Anesthesiology,2011,27(1). |
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| Authors: | WU Shu-ning DING Han-lin LI Ming-qiang |
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| Institution: | WU Shu-ning,DING Han-lin,LI Ming-qiang,et al. Department of Anesthesiology,Affiliated Xiangfan Hospital,Huazhong University of Science and Technology,Xiangfan 441021,China |
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| Abstract: | Objective To observe the effects of tramadol on T-lymphocyte subsets,activated T cells and natural killer(NK)cells in patients undergoing gastrointestinal cancer surgeries.Methods Thirty patients undergoing selective gastric cancer surgeries were randomly divided into 2 groups.Experimental group(E)was given tramadol 1 mg/kg intramuscularly before anesthesia and control group(C)was not.CD3+,CD3+CD4+,CD3+CD8+,CD3-CD16+CD56+(NK)cells and CD3+HLA-DR+(activated T cell)were measured by flow cytometery before anes... |
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| Keywords: | Tramadol Gastric cancer T-lymphocyte subsets Natural killer cells |
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