2型糖尿病患者血浆脂联素、同型半胱氨酸水平与血管内皮功能的关系

目的探讨2型糖尿病患者的血浆脂联素、同型半胱氨酸（Hcy）水平及其与血管的内皮功能的关系。方法选择2型糖尿病患者56例和健康体检者48例为对照组，用酶联免疫吸附法（ELISA）测定患者血浆Hcy和脂联素水平，用Celermajer法测定血管内皮功能。结果2型糖尿病组血浆Hcy水平明显高于对照组（P〈0．01）；而血浆脂联素水平、内皮依赖性血管舒张功能（EDD）及非内皮依赖性血管舒张功能（EID）分别低于对照组（P〈0．01）。EED与血浆Hcy呈负相关，而与脂联素呈正相关。结论2型糖尿病患者血浆Hcy水平升高，而脂联素水平减低，提示血浆Hcy升高以及脂联素的降低是2型糖尿病内皮功能损伤的重要的因素，测定血浆Hcy、脂联素和EDD可以反映2型糖尿病患者血管病变情况。

The relationship between plasma homocysteine, Adiponectin levels and endothelium dependent vasodilatation function in patients with type 2 diabetic

Objective To investigate the relationship between plasma homocysteine （Hcy）, Adiponecfin（APN） levels and endothelium dependent dilatation in the type 2 diabetic patients. Methods 56 patients with type 2 diabetic and 48 healthy controls enrolled the study. ELISA method was used to determine the homcysteine and APN levels. The vascular endothelium dependent dilatation function was evaluated by celermajer＇ s method. Results The plasma Hcy levels in the type 2 diabetic patients were higher than those in controls significantly （ P〈0.01 ）, but the plasma APN level 、EDD and EID in the type 2 diabetic patients were lower than those in controls（ P 〈 0.01 ）. There was a negative correlation between the plasma Hcy levels and EDD;and was a positive correlation between the plasma Hcy levels and EDD. Concluslons The plasma Hcy increased and APN decreased in the type 2 diabetic patients, show that are the significant factors that could damage endothelium. Plasma Hcy, APN levels and EDD detected can reflect the vascular lesions in type 2 diabetes.