成年健康个体肾小球滤过率正常范围的研究

目的探讨成年健康个体肾小球滤过率（GFR）的正常范围。方法收集不同地域的成年健康个体，以双血浆法^99m锝-二乙三胺五乙酸（^99mTc—DTPA）血浆清除率为GFR参考值（rGFR）。结果入选健康个体301名。50岁之前rGFR保持恒定；50岁之后rGFR平均每10年下降12．2ml／min。50岁之前女性的rGFR高于男性；〉50岁之后，女性的rGFR均低于男性，但差异无显著性（P〉0．05）。结论50岁以后，成年健康个体GFR真实值随着年龄的增加逐渐下降；50岁之前，女性GFR平均值高于男性。

The normal range of Glomerular Filtration Rate in Chinese apparently healthy adults

Objectives Studies show that Glomerular Filtration Rate （GFR） decrease with the increase of age,but the normal reference range of GFR by age groups in healthy Chinese adults is still unknown. The aim of this study was to investigate the normal GFR reference range by age groups in healthy Chinese adults, and to explore sex and agerelated differences in GFR. Methods Three hundred and one Chinese healthy adults were enrolled. All eligible subjects were ： （ 1 ） no positive finding by physical examination ; （ 2 ） without any kinds of chronic disease ; （ 3 ） fasting plasma glucose was normal and urinary dipstick test and sediments examination were negative. Reference GFR（rGFR） was measured using dual plasma sampling method of plasma clearance of ^99mTc-DTPA. Results The normal reference of GFR kept constant with age up to 50 years, and showed a decline after the age of 50 years with the increase of age in healthy Chinese adults, the decreased average value of rGFR after the age of 50 years was 12.2 ml/min/10 years（P 〈 0. 001 compared with those of age up to 50 years）. In the age of 18to 49 years old, the mean GFR values of females was higher than those of males（ P 〈 0.05 in the age 18 to 29, without significant difference in the age 30 to 49） ; after the age of 50, the mean GFR values of female was lower than those of male,but without significant difference. Conclusions We firstly report of the reference GFR range and sex- and age- related differences in GFR in a population of healthy Chinese subjects. These findings might be useful to evaluate normal renal function,and identify chronic kidney disease（CKD） in general population.